6GK8

Crystal structure of anti-tau antibody dmCBTAU-28.1, double mutant (S32R, E35K) of CBTAU-28.1, in complex with Tau peptide A7731 (residues 52-71)

Summary for 6GK8

• Entry DOI: 10.2210/pdb6gk8/pdb
• Related: 5ZV3 6DCV 6DCW
• Descriptor: HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-28.1(S32R;E35K), TAU PEPTIDE A7731 (RESIDUES 52-71), CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: antibody, fab, tau, complex, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 50367.25

Authors

Steinbacher, S.,Mrosek, M.,Juraszek, J. (deposition date: 2018-05-18, release date: 2018-06-13)

• Primary citation: Apetri, A.,Crespo, R.,Juraszek, J.,Pascual, G.,Janson, R.,Zhu, X.,Zhang, H.,Keogh, E.,Holland, T.,Wadia, J.,Verveen, H.,Siregar, B.,Mrosek, M.,Taggenbrock, R.,Ameijde, J.,Inganas, H.,van Winsen, M.,Koldijk, M.H.,Zuijdgeest, D.,Borgers, M.,Dockx, K.,Stoop, E.J.M.,Yu, W.,Brinkman-van der Linden, E.C.,Ummenthum, K.,van Kolen, K.,Mercken, M.,Steinbacher, S.,de Marco, D.,Hoozemans, J.J.,Wilson, I.A.,Koudstaal, W.,Goudsmit, J.; A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.; Acta Neuropathol Commun, 6:43-43, 2018; PubMed: 29855358; DOI: 10.1186/s40478-018-0543-z

Experimental method

X-RAY DIFFRACTION (2.85 Å)