6H0E

FAB dmCBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-23

Summary for 6H0E

• Entry DOI: 10.2210/pdb6h0e/pdb
• Descriptor: HUMAN FAB ANTIBODY FRAGMENT OF dmCBTAU-22.1, Microtubule-associated protein tau, GLYCEROL, ... (5 entities in total)
• Functional Keywords: fab, tau peptide, complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 202205.56

Authors

Juraszek, J.,Steinbacher, S. (deposition date: 2018-07-09, release date: 2018-07-25, Last modification date: 2020-03-11)

• Primary citation: van Ameijde, J.,Crespo, R.,Janson, R.,Juraszek, J.,Siregar, B.,Verveen, H.,Sprengers, I.,Nahar, T.,Hoozemans, J.J.,Steinbacher, S.,Willems, R.,Delbroek, L.,Borgers, M.,Dockx, K.,Van Kolen, K.,Mercken, M.,Pascual, G.,Koudstaal, W.,Apetri, A.; Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau.; Acta Neuropathol Commun, 6:59-59, 2018; PubMed: 30001207; DOI: 10.1186/s40478-018-0562-9

Experimental method

X-RAY DIFFRACTION (1.95 Å)