9J1T
 
 | | Structure of a triple-helix region of human Collagen type IV from Trautec | | 分子名称: | GLYCEROL, Triple-helix region of human collagen type IV | | 著者 | Fan, X, Chu, Y, Zhai, Y, Fu, S, Li, D, Feng, P, Cao, K, Wu, X, Cai, H, Wang, H, Qian, S. | | 登録日 | 2024-08-05 | | 公開日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structure of a triple-helix region of human Collagen type IV from Trautec
To Be Published
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8K9R
 | | Cryo EM structure of the products-bound PGAP1(Bst1)-H443N from Chaetomium thermophilum | | 分子名称: | 2-amino-2-deoxy-alpha-D-glucopyranose, 2-azanylethyl [(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate, 2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate, ... | | 著者 | Li, T, Hong, J, Qu, Q, Li, D. | | 登録日 | 2023-08-01 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.
Nat Commun, 15, 2024
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8K9Q
 | | Cryo-EM structure of the GPI inositol-deacylase (PGAP1/Bst1) from Chaetomium thermophilum | | 分子名称: | (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, CHOLESTEROL HEMISUCCINATE, GPI inositol-deacylase,fused thermostable green fluorescent protein | | 著者 | Hong, J, Li, T, Qu, Q, Li, D. | | 登録日 | 2023-08-01 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.
Nat Commun, 15, 2024
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8K9T
 | | Cryo-EM structure of the products-bound PGAP1(Bst1)-S327A from Chaetonium thermophilum | | 分子名称: | 2-amino-2-deoxy-alpha-D-glucopyranose, 2-azanylethyl [(2R,3S,4S,5S,6S)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate, 2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate, ... | | 著者 | Li, T, Hong, J, Qu, Q, Li, D. | | 登録日 | 2023-08-01 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.
Nat Commun, 15, 2024
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9J26
 | | Structure of a triple-helix region of human Collagen type IV from Trautec | | 分子名称: | Triple-helix region of human collagen type IV | | 著者 | Fan, X, Zhai, Y, Chu, Y, Fu, S, Li, D, Cao, K, Feng, P, Wu, X, Cai, H, Ma, L, Qian, S. | | 登録日 | 2024-08-06 | | 公開日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structure of a triple-helix region of human Collagen type IV from Trautec
To Be Published
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5XSG
 | | Ultrahigh resolution structure of FUS (37-42) SYSGYS determined by MicroED | | 分子名称: | RNA-binding protein FUS | | 著者 | Luo, F, Gui, X, Zhou, H, Li, D, Li, X, Liu, C. | | 登録日 | 2017-06-14 | | 公開日 | 2018-04-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (0.73 Å) | | 主引用文献 | Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation.
Nat. Struct. Mol. Biol., 25, 2018
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6A6B
 | | cryo-em structure of alpha-synuclein fiber | | 分子名称: | Alpha-synuclein | | 著者 | Li, Y.W, Zhao, C.Y, Luo, F, Liu, Z, Gui, X, Luo, Z, Zhang, X, Li, D, Liu, C, Li, X. | | 登録日 | 2018-06-27 | | 公開日 | 2018-07-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Amyloid fibril structure of alpha-synuclein determined by cryo-electron microscopy
Cell Res., 28, 2018
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5ZO2
 | | Crystal structure of mouse nectin-like molecule 4 (mNecl-4) full ectodomain in complex with mouse nectin-like molecule 1 (mNecl-1) Ig1 domain, 3.3A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Cell adhesion molecule 3, Cell adhesion molecule 4 | | 著者 | Liu, X, An, T, Li, D, Fan, Z, Xiang, P, Li, C, Ju, W, Li, J, Hu, G, Qin, B, Yin, B, Wojdyla, J.A, Wang, M, Yuan, J, Qiang, B, Shu, P, Cui, S, Peng, X. | | 登録日 | 2018-04-12 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Structure of the heterophilic interaction between the nectin-like 4 and nectin-like 1 molecules.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7CYV
 | | Crystal structure of FD20, a neutralizing single-chain variable fragment (scFv) in complex with SARS-CoV-2 Spike receptor-binding domain (RBD) | | 分子名称: | Spike protein S1, The heavy chain variable region of the scFv FD20,The light chain variable region of the scFv FD20, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Li, Y, Li, T, Lai, Y, Cai, H, Yao, H, Li, D. | | 登録日 | 2020-09-04 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | | 主引用文献 | Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody.
Embo Mol Med, 13, 2021
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5ZO1
 | | Crystal structure of mouse nectin-like molecule 4 (mNecl-4) full ectodomain (Ig1-Ig3), 2.2A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Cell adhesion molecule 4, GLYCEROL | | 著者 | Liu, X, An, T, Li, D, Fan, Z, Xiang, P, Li, C, Ju, W, Li, J, Hu, G, Qin, B, Yin, B, Wojdyla, J.A, Wang, M, Yuan, J, Qiang, B, Shu, P, Cui, S, Peng, X. | | 登録日 | 2018-04-12 | | 公開日 | 2019-01-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | | 主引用文献 | Structure of the heterophilic interaction between the nectin-like 4 and nectin-like 1 molecules.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7WQV
 | | Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Ab08, ... | | 著者 | Zha, J, Meng, L, Zhang, X, Li, D. | | 登録日 | 2022-01-26 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy.
Plos Pathog., 19, 2023
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1I1H
 | | CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE COMPLEX WITH HYDROGENOBYRINIC ACID | | 分子名称: | HYDROGENOBYRINIC ACID, PRECORRIN-8X METHYLMUTASE | | 著者 | Shipman, L.W, Li, D, Roessner, C.A, Scott, A.I, Sacchettini, J.C. | | 登録日 | 2001-02-01 | | 公開日 | 2001-07-18 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of precorrin-8x methyl mutase.
Structure, 9, 2001
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7F5G
 | | The crystal structure of RBD-Nanobody complex, DL4 (SA4) | | 分子名称: | ACETATE ION, GLYCEROL, Nanobody DL4, ... | | 著者 | Li, T, Lai, Y, Zhou, Y, Tan, J, Li, D. | | 登録日 | 2021-06-22 | | 公開日 | 2022-05-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2.
Int.J.Biol.Macromol., 209, 2022
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7F5H
 | | The crystal structure of RBD-Nanobody complex, DL28 (SC4) | | 分子名称: | GLYCEROL, Nanobody DL28, PHOSPHATE ION, ... | | 著者 | Luo, Z.P, Li, T, Lai, Y, Zhou, Y, Tan, J, Li, D. | | 登録日 | 2021-06-22 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants.
Front Microbiol, 13, 2022
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8X7P
 | | CCA-bound E46K alpha-synuclein fibrils | | 分子名称: | Alpha-synuclein, copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate | | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | | 登録日 | 2023-11-24 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8X7R
 | | C05-03-bound E46K alpha-synuclein fibrils | | 分子名称: | 2-[(~{E})-4-[6-(methylamino)pyridin-3-yl]but-1-en-3-ynyl]-1,3-benzothiazol-6-ol, Alpha-synuclein | | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | | 登録日 | 2023-11-24 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8X7Q
 | | pFTAA-bound E46K alpha-synuclein fibrils | | 分子名称: | 3''',4'-bis(carboxymethyl)-2,2':5',2'':5'',2''':5''',2''''-quinquethiophene-5,5''''-dicarboxylic acid, Alpha-synuclein | | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | | 登録日 | 2023-11-24 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8X7O
 | | PiB-bound E46K mutanted alpha-synuclein fibrils | | 分子名称: | 2-[4-(methylamino)phenyl]-1,3-benzothiazol-6-ol, Alpha-synuclein | | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | | 登録日 | 2023-11-24 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8X7M
 | | CR-bound E46K alpha-synuclein fibrils | | 分子名称: | 4-azanyl-3-[(~{E})-[4-[4-[(~{E})-(1-azanyl-4-sulfo-naphthalen-2-yl)diazenyl]phenyl]phenyl]diazenyl]naphthalene-1-sulfonic acid, Alpha-synuclein | | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | | 登録日 | 2023-11-24 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8X7L
 | | EB-bound E46K alpha-synuclein fibrils | | 分子名称: | 4-azanyl-6-[[4-[4-[(~{E})-(8-azanyl-1-oxidanyl-5,7-disulfo-naphthalen-2-yl)diazenyl]-3-methyl-phenyl]-2-methyl-phenyl]diazenyl]-5-oxidanyl-naphthalene-1,3-disulfonic acid, Alpha-synuclein | | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | | 登録日 | 2023-11-24 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5JDB
 | | Binding specificity of P[8] VP8* proteins of rotavirus vaccine strains with histo-blood group antigens | | 分子名称: | Outer capsid protein VP4 | | 著者 | Sun, X, Guo, N, Li, D, Zhou, Y, Jin, M, Xie, G, Pang, L, Zhang, Q, Cao, Y, Duan, Z. | | 登録日 | 2016-04-16 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Binding specificity of P[8] VP8* proteins of rotavirus vaccine strains with histo-blood group antigens.
Virology, 495, 2016
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4NC3
 | | Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase. | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHOLESTEROL, ... | | 著者 | Liu, W, Wacker, D, Gati, C, Han, G.W, James, D, Wang, D, Nelson, G, Weierstall, U, Katritch, V, Barty, A, Zatsepin, N.A, Li, D, Messerschmidt, M, Boutet, S, Williams, G.J, Koglin, J.E, Seibert, M.M, Wang, C, Shah, S.T.A, Basu, S, Fromme, R, Kupitz, C, Rendek, K.N, Grotjohann, I, Fromme, P, Kirian, R.A, Beyerlein, K.R, White, T.A, Chapman, H.N, Caffrey, M, Spence, J.C.H, Stevens, R.C, Cherezov, V, GPCR Network (GPCR) | | 登録日 | 2013-10-23 | | 公開日 | 2013-12-18 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Serial femtosecond crystallography of G protein-coupled receptors.
Science, 342, 2013
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8PPO
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8Q2J
 | | Tau - AD-MIA2 | | 分子名称: | Isoform Tau-D of Microtubule-associated protein tau | | 著者 | Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. | | 登録日 | 2023-08-02 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (2.23 Å) | | 主引用文献 | Disease-specific tau filaments assemble via polymorphic intermediates.
Nature, 625, 2024
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8Q27
 | | Tau: AD-MIA1 | | 分子名称: | Isoform Tau-D of Microtubule-associated protein tau | | 著者 | Lovestam, S, Scheres, S.H.W, Goedert, M, Li, D. | | 登録日 | 2023-08-01 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (2.02 Å) | | 主引用文献 | Disease-specific tau filaments assemble via polymorphic intermediates.
Nature, 625, 2024
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