7WQV

Crystal structure of a neutralizing monoclonal antibody (Ab08) in complex with SARS-CoV-2 receptor-binding domain (RBD)

Summary for 7WQV

• Entry DOI: 10.2210/pdb7wqv/pdb
• Descriptor: Spike protein S1, Ab08, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: ab08, mab, coronavirus, covid-19, monoclonal antibody, nab, neutralizing antibody, rbd, receptor-binding domain, sars-cov-2, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 16
• Total formula weight: 463813.98

Authors

Zha, J.,Meng, L.,Zhang, X.,Li, D. (deposition date: 2022-01-26, release date: 2023-01-25, Last modification date: 2023-11-29)

• Primary citation: Meng, L.,Zha, J.,Zhou, B.,Cao, L.,Jiang, C.,Zhu, Y.,Li, T.,Lu, L.,Zhang, J.,Yang, H.,Feng, J.,Gu, Z.,Tang, H.,Jiang, L.,Li, D.,Lavillette, D.,Zhang, X.; A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy.; Plos Pathog., 19:e1011085-e1011085, 2023; PubMed: 36706160; DOI: 10.1371/journal.ppat.1011085

Experimental method

X-RAY DIFFRACTION (2.8 Å)