8Q2J

Tau - AD-MIA2

Summary for 8Q2J

• Entry DOI: 10.2210/pdb8q2j/pdb
• EMDB information: 18109
• Descriptor: Isoform Tau-D of Microtubule-associated protein tau (1 entity in total)
• Functional Keywords: amyloid, tau, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 240016.64

Authors

Lovestam, S.,Li, D.,Scheres, S.H.W.,Goedert, M. (deposition date: 2023-08-02, release date: 2023-08-30, Last modification date: 2024-01-24)

• Primary citation: Lovestam, S.,Li, D.,Wagstaff, J.L.,Kotecha, A.,Kimanius, D.,McLaughlin, S.H.,Murzin, A.G.,Freund, S.M.V.,Goedert, M.,Scheres, S.H.W.; Disease-specific tau filaments assemble via polymorphic intermediates.; Nature, 625:119-125, 2024; PubMed: 38030728; DOI: 10.1038/s41586-023-06788-w

Experimental method

ELECTRON MICROSCOPY (2.23 Å)