8PPO

First Intermediate Amyloid (FIA) - Tau

Summary for 8PPO

Entry DOI	10.2210/pdb8ppo/pdb
EMDB information	17806
Descriptor	Microtubule-associated protein tau (1 entity in total)
Functional Keywords	amyloid, tau, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	16
Total formula weight	734717.94
Authors	Lovestam, S.,Scheres, S.H.W.,Goedert, M.,Li, D. (deposition date: 2023-07-07, release date: 2023-08-02, Last modification date: 2024-01-24)
Primary citation	Lovestam, S.,Li, D.,Wagstaff, J.L.,Kotecha, A.,Kimanius, D.,McLaughlin, S.H.,Murzin, A.G.,Freund, S.M.V.,Goedert, M.,Scheres, S.H.W. Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625:119-125, 2024 Cited by PubMed: 38030728 DOI: 10.1038/s41586-023-06788-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2 Å)

Structure validation