7CYV

Crystal structure of FD20, a neutralizing single-chain variable fragment (scFv) in complex with SARS-CoV-2 Spike receptor-binding domain (RBD)

Summary for 7CYV

• Entry DOI: 10.2210/pdb7cyv/pdb
• Descriptor: The heavy chain variable region of the scFv FD20,The light chain variable region of the scFv FD20, Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: coronavirus, covid-19, ncov-2019, neutralizing antibody, receptor-binding domain, sars-cov-2, scfv, single-chain variable fragment, spike, viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 54319.98

Authors

Li, Y.,Li, T.,Lai, Y.,Cai, H.,Yao, H.,Li, D. (deposition date: 2020-09-04, release date: 2021-09-15, Last modification date: 2023-11-29)

• Primary citation: Li, T.,Cai, H.,Zhao, Y.,Li, Y.,Lai, Y.,Yao, H.,Liu, L.D.,Sun, Z.,van Vlissingen, M.F.,Kuiken, T.,GeurtsvanKessel, C.H.,Zhang, N.,Zhou, B.,Lu, L.,Gong, Y.,Qin, W.,Mondal, M.,Duan, B.,Xu, S.,Richard, A.S.,Raoul, H.,Chen, J.,Xu, C.,Wu, L.,Zhou, H.,Huang, Z.,Zhang, X.,Li, J.,Wang, Y.,Bi, Y.,Rockx, B.,Chen, J.,Meng, F.L.,Lavillette, D.,Li, D.; Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody.; Embo Mol Med, 13:e14544-e14544, 2021; PubMed: 34672091; DOI: 10.15252/emmm.202114544

Experimental method

X-RAY DIFFRACTION (3.13 Å)