7CYV

Crystal structure of FD20, a neutralizing single-chain variable fragment (scFv) in complex with SARS-CoV-2 Spike receptor-binding domain (RBD)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	The heavy chain variable region of the scFv FD20,The light chain variable region of the scFv FD20	polymer	281	29613.5	1		Homo sapiens
2	B (B)	Spike protein S1	polymer	213	23827.6	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein
3	C (A)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		878.8	1	In PDB GlyTouCan (G92953ND)

Sequence modifications

H: -4 - 127 (PDB: 7CYV)
H: 987 - 1135 (PDB: 7CYV)
B: 330 - 531 (UniProt: P0DTC2)

PDB	External Database	Details
Ala 327	-	expression tag
Gly 328	-	expression tag
Ser 329	-	expression tag
Gly 532	-	expression tag
Thr 533	-	expression tag
Leu 534	-	expression tag
Glu 535	-	expression tag
Val 536	-	expression tag
Leu 537	-	expression tag
Phe 538	-	expression tag
Gln 539	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	53441.2
Branched	Number of molecules	1
	Total formula weight	878.8
All*	Total formula weight	54320.0

*Water molecules are not included.