7CYV
Crystal structure of FD20, a neutralizing single-chain variable fragment (scFv) in complex with SARS-CoV-2 Spike receptor-binding domain (RBD)
Summary for 7CYV
Entry DOI | 10.2210/pdb7cyv/pdb |
Descriptor | The heavy chain variable region of the scFv FD20,The light chain variable region of the scFv FD20, Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | coronavirus, covid-19, ncov-2019, neutralizing antibody, receptor-binding domain, sars-cov-2, scfv, single-chain variable fragment, spike, viral protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 54319.98 |
Authors | |
Primary citation | Li, T.,Cai, H.,Zhao, Y.,Li, Y.,Lai, Y.,Yao, H.,Liu, L.D.,Sun, Z.,van Vlissingen, M.F.,Kuiken, T.,GeurtsvanKessel, C.H.,Zhang, N.,Zhou, B.,Lu, L.,Gong, Y.,Qin, W.,Mondal, M.,Duan, B.,Xu, S.,Richard, A.S.,Raoul, H.,Chen, J.,Xu, C.,Wu, L.,Zhou, H.,Huang, Z.,Zhang, X.,Li, J.,Wang, Y.,Bi, Y.,Rockx, B.,Chen, J.,Meng, F.L.,Lavillette, D.,Li, D. Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody. Embo Mol Med, 13:e14544-e14544, 2021 Cited by PubMed: 34672091DOI: 10.15252/emmm.202114544 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.13 Å) |
Structure validation
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