8X7P

CCA-bound E46K alpha-synuclein fibrils

Summary for 8X7P

• Entry DOI: 10.2210/pdb8x7p/pdb
• EMDB information: 38106
• Descriptor: Alpha-synuclein, copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate (2 entities in total)
• Functional Keywords: amyloid fibril, complex, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 150027.37

Authors

Liu, K.E.,Tao, Y.Q.,Li, D.,Liu, C. (deposition date: 2023-11-24, release date: 2024-09-11)

• Primary citation: Liu, K.,Tao, Y.,Zhao, Q.,Xia, W.,Li, X.,Zhang, S.,Yao, Y.,Xiang, H.,Han, C.,Tan, L.,Sun, B.,Li, D.,Li, A.,Liu, C.; Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.; Proc.Natl.Acad.Sci.USA, 121:e2321633121-e2321633121, 2024; PubMed: 39172784; DOI: 10.1073/pnas.2321633121

Experimental method

ELECTRON MICROSCOPY (2.7 Å)