8K9Q

Cryo-EM structure of the GPI inositol-deacylase (PGAP1/Bst1) from Chaetomium thermophilum

Summary for 8K9Q

• Entry DOI: 10.2210/pdb8k9q/pdb
• EMDB information: 36995
• Descriptor: GPI inositol-deacylase,fused thermostable green fluorescent protein, CHOLESTEROL HEMISUCCINATE, (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid (3 entities in total)
• Functional Keywords: bst1, glycosylphosphatidylinositol, gpi anchoring, gpi-ap, gpi-ap remodelase, integral membrane enzyme, lipase, lipid remodeling, membrane enzyme, membrane protein, nanodisc, pgap1, transmembrane enzyme, triad enzyme
• Biological source: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila); More
• Total number of polymer chains: 1
• Total formula weight: 166137.28

Authors

Hong, J.,Li, T.,Qu, Q.,Li, D. (deposition date: 2023-08-01, release date: 2023-12-20, Last modification date: 2024-01-17)

• Primary citation: Hong, J.,Li, T.,Chao, Y.,Xu, Y.,Zhu, Z.,Zhou, Z.,Gu, W.,Qu, Q.,Li, D.; Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.; Nat Commun, 15:8-8, 2024; PubMed: 38167496; DOI: 10.1038/s41467-023-44568-2

Experimental method

ELECTRON MICROSCOPY (2.84 Å)