4RG1
 
 | | Methyltransferase domain of C9orf114 | | 分子名称: | C9orf114, POLYETHYLENE GLYCOL (N=34), S-1,2-PROPANEDIOL, ... | | 著者 | Dong, A, Zeng, H, Walker, J.R, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2014-09-29 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | The Crystal Structure of Human C9orf114 in complex with S-adenosyl-homocysteine
To be Published
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5GJ4
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5H43
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8Y6P
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5H4I
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5FRS
 | | Structure of the Pds5-Scc1 complex and implications for cohesin function | | 分子名称: | SISTER CHROMATID COHESION PROTEIN 1, SISTER CHROMATID COHESION PROTEIN PDS5 | | 著者 | Muir, K.W, Kschonsak, M, Li, Y, Metz, J, Haering, C.H, Panne, D. | | 登録日 | 2015-12-22 | | 公開日 | 2016-03-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (4.073 Å) | | 主引用文献 | Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function
Cell Rep., 14, 2016
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8Z1E
 | | A homotrimeric GPCR architecture of the human cytomegalovirus (UL78) revealed by cryo-EM | | 分子名称: | Uncharacterized protein UL78 | | 著者 | Chen, Y, Li, Y, Zhou, Q, Cong, Z, Lin, S, Yan, J, Chen, X, Yang, D, Ying, T, Wang, M.-W. | | 登録日 | 2024-04-11 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM.
Cell Discov, 10, 2024
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5FRP
 | | Structure of the Pds5-Scc1 complex and implications for cohesin function | | 分子名称: | MCD1-LIKE PROTEIN, SISTER CHROMATID COHESION PROTEIN PDS5 | | 著者 | Muir, K.W, Kschonsak, M, Li, Y, Metz, J, Haering, C.H, Panne, D. | | 登録日 | 2015-12-21 | | 公開日 | 2016-03-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.895 Å) | | 主引用文献 | Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function
Cell Rep., 14, 2016
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4RO0
 | | Crystal structure of MthK gating ring in a ligand-free form | | 分子名称: | Calcium-gated potassium channel MthK | | 著者 | Dong, W, Guo, R, Chai, H, Chen, Z, Cui, H, Ren, Z, Li, Y, Ye, S. | | 登録日 | 2014-10-27 | | 公開日 | 2015-10-28 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | The principle of cooperative gating in a calcium-gated K+ channel
To be Published
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4HJJ
 | | Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule | | 分子名称: | Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, CHLORIDE ION, ... | | 著者 | Jakob, C.G, Edalji, R, Judge, R.A, DiGiammarino, E, Li, Y, Gu, J, Ghayur, T. | | 登録日 | 2012-10-12 | | 公開日 | 2013-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule
MAbs, 5, 2013
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3S44
 | | Crystal Structure of Pasteurella multocida sialyltransferase M144D mutant with CMP bound | | 分子名称: | Alpha-2,3/2,6-sialyltransferase/sialidase, CMP-3F(a)-Neu5Ac | | 著者 | Sugiarto, G, Lau, K, Li, Y, Lim, S, Ames, J.B, Le, D.-T, Fisher, A.J, Chen, X. | | 登録日 | 2011-05-18 | | 公開日 | 2012-08-15 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | A Sialyltransferase Mutant with Decreased Donor Hydrolysis and Reduced Sialidase Activities for Directly Sialylating Lewis(x).
Acs Chem.Biol., 7, 2012
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3S6K
 | | Crystal structure of xcNAGS | | 分子名称: | Acetylglutamate kinase | | 著者 | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | | 登録日 | 2011-05-25 | | 公開日 | 2012-04-18 | | 実験手法 | X-RAY DIFFRACTION (2.8018 Å) | | 主引用文献 | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris.
Plos One, 6, 2011
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3S7Y
 | | Crystal structure of mmNAGS in Space Group P3121 at 4.3 A resolution | | 分子名称: | N-acetylglutamate kinase / N-acetylglutamate synthase | | 著者 | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | | 登録日 | 2011-05-27 | | 公開日 | 2012-04-18 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (4.3077 Å) | | 主引用文献 | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris.
Plos One, 6, 2011
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4IJ8
 | | Crystal structure of the complex of SETD8 with SAM | | 分子名称: | N-lysine methyltransferase SETD8, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ... | | 著者 | Yu, W, Tempel, W, Li, Y, El Bakkouri, M, Shapira, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2012-12-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the complex of SETD8 with SAM
To be Published
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2C7U
 | | Conflicting selective forces affect CD8 T-cell receptor contact sites in an HLA-A2 immunodominant HIV epitope. | | 分子名称: | BETA-2-MICROGLOBULIN, GAG PROTEIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ... | | 著者 | Iversen, A.K, Stewart-Jones, G, Learn, G.H, Christie, N, Sylvester-Hviid, C, Armitage, A.E, Kaul, R, Beattie, T, Lee, J.K, Li, Y, Chotiyarnwong, P, Dong, T, Xu, X, Luscher, M.A, MacDonald, K, Ullum, H, Klarlund-Pedersen, B, Skinhoj, P, Fugger, J.L, Buus, S, Mullins, J.I, Jones, E.Y, van der Merwe, P.A, McMichael, A.J. | | 登録日 | 2005-11-29 | | 公開日 | 2006-03-08 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Conflicting Selective Forces Affect T Cell Receptor Contacts in an Immunodominant Human Immunodeficiency Virus Epitope.
Nat.Immunol., 7, 2006
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3S6G
 | | Crystal structures of Seleno-substituted mutant mmNAGS in space group P212121 | | 分子名称: | 1,2-ETHANEDIOL, COENZYME A, MALONATE ION, ... | | 著者 | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | | 登録日 | 2011-05-25 | | 公開日 | 2012-04-18 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6681 Å) | | 主引用文献 | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris.
Plos One, 6, 2011
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3S6H
 | | Crystal structure of native mmNAGS/k | | 分子名称: | COENZYME A, GLUTAMIC ACID, N-acetylglutamate kinase / N-acetylglutamate synthase | | 著者 | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | | 登録日 | 2011-05-25 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.102 Å) | | 主引用文献 | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris.
Plos One, 6, 2011
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3SP6
 | | Structural basis for iloprost as a dual PPARalpha/delta agonist | | 分子名称: | (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid, Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-beta | | 著者 | Rong, H, Li, Y. | | 登録日 | 2011-07-01 | | 公開日 | 2011-07-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist.
J.Biol.Chem., 286, 2011
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4H5S
 | | Complex structure of Necl-2 and CRTAM | | 分子名称: | Cell adhesion molecule 1, Cytotoxic and regulatory T-cell molecule | | 著者 | Zhang, S, Lu, G, Qi, J, Li, Y, Zhang, Z, Zhang, B, Yan, J, Gao, G.F. | | 登録日 | 2012-09-18 | | 公開日 | 2013-08-07 | | 最終更新日 | 2022-08-24 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Competition of cell adhesion and immune recognition: insights into the interaction between CRTAM and nectin-like 2.
Structure, 21, 2013
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8JR9
 | | Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R) | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha-1, ... | | 著者 | Zhao, L, He, Q, Yuan, Q, Gu, Y, He, X, Shan, H, Li, J, Wang, K, Li, Y, Hu, W, Wu, K, Shen, J, Xu, H.E. | | 登録日 | 2023-06-16 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | Conserved class B GPCR activation by a biased intracellular agonist.
Nature, 621, 2023
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2AWZ
 | | Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h) | | 分子名称: | 5R-(4-BROMOPHENYLMETHYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | | 著者 | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | | 登録日 | 2005-09-02 | | 公開日 | 2006-01-24 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase.
J.Med.Chem., 49, 2006
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3SP9
 | | Structural basis for iloprost as a dual PPARalpha/delta agonist | | 分子名称: | (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid, Peroxisome proliferator-activated receptor delta | | 著者 | Rong, H, Li, Y. | | 登録日 | 2011-07-01 | | 公開日 | 2011-07-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist.
J.Biol.Chem., 286, 2011
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2AI3
 | | Purine nucleoside phosphorylase from calf spleen | | 分子名称: | (2S,4R,6R,6AS)-4-(2-AMINO-6-OXO-1,6-DIHYDROPURIN-9-YL)-6-(HYDROXYMETHYL)-TETRAHYDROFURO[3,4-D][1,3]DIOXOL-2-YLPHOSPHONI C ACID, MAGNESIUM ION, Purine nucleoside phosphorylase, ... | | 著者 | Toms, A.V, Wang, W, Li, Y, Ganem, B, Ealick, S.E. | | 登録日 | 2005-07-28 | | 公開日 | 2005-10-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase.
Acta Crystallogr.,Sect.D, 61, 2005
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2B2X
 | | VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab | | 分子名称: | Antibody AQC2 Fab, Integrin alpha-1, MAGNESIUM ION | | 著者 | Clark, L.A, Boriack-Sjodin, P.A, Eldredge, J, Fitch, C, Friedman, B, Hanf, K.J, Jarpe, M, Liparoto, S.F, Li, Y, Lugovskoy, A. | | 登録日 | 2005-09-19 | | 公開日 | 2006-04-18 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design
Protein Sci., 15, 2006
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2AHU
 | | Crystal structure of Acyl-CoA transferase (YdiF) apoenzyme from Escherichia coli O157:H7. | | 分子名称: | putative enzyme ydiF | | 著者 | Rangarajan, E.S, Li, Y, Ajamian, E, Iannuzzi, P, Kernaghan, S.D, Fraser, M.E, Cygler, M, Matte, A, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | | 登録日 | 2005-07-28 | | 公開日 | 2005-11-01 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I CoA transferases.
J.Biol.Chem., 280, 2005
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