2B2X

VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab

Summary for 2B2X

• Entry DOI: 10.2210/pdb2b2x/pdb
• Related: 1MHP
• Descriptor: Integrin alpha-1, Antibody AQC2 Fab, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: computational design, antibody-antigen complex, immune system
• Biological source: Rattus norvegicus (Norway rat); More
• Cellular location: Membrane; Single-pass type I membrane protein: P18614
• Total number of polymer chains: 6
• Total formula weight: 145643.02

Authors

Clark, L.A.,Boriack-Sjodin, P.A.,Eldredge, J.,Fitch, C.,Friedman, B.,Hanf, K.J.,Jarpe, M.,Liparoto, S.F.,Li, Y.,Lugovskoy, A. (deposition date: 2005-09-19, release date: 2006-04-18, Last modification date: 2023-08-23)

• Primary citation: Clark, L.A.,Boriack-Sjodin, P.A.,Eldredge, J.,Fitch, C.,Friedman, B.,Hanf, K.J.,Jarpe, M.,Liparoto, S.F.,Li, Y.,Lugovskoy, A.,Miller, S.,Rushe, M.,Sherman, W.,Simon, K.,Van Vlijmen, H.; Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design; Protein Sci., 15:949-960, 2006; PubMed: 16597831; DOI: 10.1110/ps.052030506

Experimental method

X-RAY DIFFRACTION (2.2 Å)