3SP9

Structural basis for iloprost as a dual PPARalpha/delta agonist

Summary for 3SP9

• Entry DOI: 10.2210/pdb3sp9/pdb
• Related: 3SP6
• Descriptor: Peroxisome proliferator-activated receptor delta, (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid (3 entities in total)
• Functional Keywords: nuclear receptor lbd, nuclear receptor fold, ligand binding, gene transcription, drug binding, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q03181
• Total number of polymer chains: 2
• Total formula weight: 65179.78

Authors

Rong, H.,Li, Y. (deposition date: 2011-07-01, release date: 2011-07-20, Last modification date: 2024-02-28)

• Primary citation: Jin, L.,Lin, S.,Rong, H.,Zheng, S.,Jin, S.,Wang, R.,Li, Y.; Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist.; J.Biol.Chem., 286:31473-31479, 2011; PubMed: 21775429; DOI: 10.1074/jbc.M111.266023

Experimental method

X-RAY DIFFRACTION (2.3 Å)