3SP9
Structural basis for iloprost as a dual PPARalpha/delta agonist
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Peroxisome proliferator-activated receptor delta | polymer | 281 | 32229.4 | 2 | UniProt (Q03181) Pfam (PF00104) In PDB | Homo sapiens (human) | PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta |
2 | A, B | (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid | non-polymer | 360.5 | 2 | Chemie (IL2) | |||
3 | water | water | 18.0 | 385 | Chemie (HOH) |
Sequence modifications
A, B: 173 - 441 (UniProt: Q03181)
PDB | External Database | Details |
---|---|---|
His 161 | - | expression tag |
His 162 | - | expression tag |
His 163 | - | expression tag |
His 164 | - | expression tag |
His 165 | - | expression tag |
His 166 | - | expression tag |
Leu 167 | - | expression tag |
Val 168 | - | expression tag |
Pro 169 | - | expression tag |
Arg 170 | - | expression tag |
Gly 171 | - | expression tag |
Ser 172 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 64458.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 721.0 | |
All* | Total formula weight | 65179.8 |