Structural and mechanistical studies of the nuclear import by Importin-alpha

Summary for 5H43

DescriptorImportin subunit alpha-1, Histone acetyltransferase KAT8, ... (4 entities in total)
Functional Keywordsimportin alpha, nuclear import, protein transport-transferase complex, protein transport/transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  P52292
Nucleus  Q9H7Z6 Q9H7Z6
Total number of polymer chains3
Total molecular weight49490.42
Wang, R.,Li, Y. (deposition date: 2016-10-28, release date: 2017-10-25, Last modification date: 2018-01-03)
Primary citation
Zheng, W.,Wang, R.,Liu, X.,Tian, S.,Yao, B.,Chen, A.,Jin, S.,Li, Y.
Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha 1
Traffic, 19:19-28, 2018
PubMed: 28991411 (PDB entries with the same primary citation)
DOI: 10.1111/tra.12534
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23810 0.2% 5.2% 1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02