4KON
| The structure of hemagglutinin from avian-origin H7N9 influenza virus in complex with human receptor analog 6'SLNLN (NeuAcα2-6Galβ1-4GlcNAcβ1-3Galβ1-4Glc) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2, ... | 著者 | Shi, Y, Zhang, W, Wang, F, Qi, J, Song, H, Wu, Y, Gao, F, Zhang, Y, Fan, Z, Gong, W, Wang, D, Shu, Y, Wang, Y, Yan, J, Gao, G.F. | 登録日 | 2013-05-12 | 公開日 | 2013-11-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science, 342, 2013
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4KOL
| The structure of hemagglutinin from avian-origin H7N9 influenza virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2 | 著者 | Shi, Y, Zhang, W, Wang, F, Qi, J, Song, H, Wu, Y, Gao, F, Zhang, Y, Fan, Z, Gong, W, Wang, D, Shu, Y, Wang, Y, Yan, J, Gao, G.F. | 登録日 | 2013-05-12 | 公開日 | 2013-11-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | 主引用文献 | Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science, 342, 2013
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8HNC
| Cryo-EM structure of human OATP1B1 in complex with bilirubin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ... | 著者 | Shan, Z, Yang, X, Liu, H, Nan, J, Yuan, Y, Zhang, Y. | 登録日 | 2022-12-07 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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8HND
| Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier organic anion transporter family member 1B1, ... | 著者 | Shan, Z, Yang, X, Liu, H, Nan, J, Yuan, Y, Zhang, Y. | 登録日 | 2022-12-07 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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8HNB
| Cryo-EM structure of human OATP1B1 in apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier organic anion transporter family member 1B1 | 著者 | Shan, Z, Yang, X, Zhang, Y. | 登録日 | 2022-12-07 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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8HNH
| Cryo-EM structure of human OATP1B1 in complex with simeprevir | 分子名称: | (2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-({7-methoxy-8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Shan, Z, Yang, X, Zhang, Y. | 登録日 | 2022-12-07 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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4KDN
| Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus in complex with avian receptor analog LSTa | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | 著者 | Lu, X, Shi, Y, Zhang, W, Zhang, Y, Qi, J, Gao, G.F. | 登録日 | 2013-04-25 | 公開日 | 2013-07-24 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.483 Å) | 主引用文献 | Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell, 4, 2013
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5ZRX
| Crystal Structure of EphA2/SHIP2 Complex | 分子名称: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2,Ephrin type-A receptor 2 | 著者 | Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M. | 登録日 | 2018-04-25 | 公開日 | 2018-05-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife, 7, 2018
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5ZRY
| Crystal Structure of EphA6/Odin Complex | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Ankyrin repeat and SAM domain-containing protein 1A,Ephrin type-A receptor 6, ... | 著者 | Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M. | 登録日 | 2018-04-25 | 公開日 | 2018-05-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife, 7, 2018
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4KDQ
| Crystal structure of the hemagglutinin of A/Xinjiang/1/2006 virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | 著者 | Lu, X, Shi, Y, Zhang, W, Zhang, Y, Qi, J, Gao, G.F. | 登録日 | 2013-04-25 | 公開日 | 2013-07-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.604 Å) | 主引用文献 | Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut). Protein Cell, 4, 2013
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5ZRZ
| Crystal Structure of EphA5/SAMD5 Complex | 分子名称: | Ephrin type-A receptor 5, Sterile alpha motif domain-containing protein 5 | 著者 | Wang, Y, Shang, Y, Li, J, Chen, W, Li, G, Wan, J, Liu, W, Zhang, M. | 登録日 | 2018-04-25 | 公開日 | 2018-05-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. Elife, 7, 2018
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7YL2
| Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004 | 分子名称: | Bromodomain-containing protein 4, GLYCEROL, N-(1-ethyl-2-oxidanylidene-3H-indol-5-yl)cyclohexanesulfonamide, ... | 著者 | Huang, Y, Wei, A, Dong, R, Xu, H, Zhang, C, Chen, Z, Li, J, Wu, X, Zhang, Y, Xu, Y. | 登録日 | 2022-07-25 | 公開日 | 2023-07-26 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004 To Be Published
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7YVR
| Crystal Structure of L-Threonine Aldolase from Neptunomonas marina | 分子名称: | GLYCEROL, L-threonine aldolase | 著者 | He, Y.Z, Wang, J, Yan, W.P, Zhang, Y, Feng, Y. | 登録日 | 2022-08-19 | 公開日 | 2023-05-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of beta-Hydroxy-alpha-amino Acids via C-C Formation Acs Catalysis, 2023
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8YUU
| Cryo-EM structure of the histamine-bound H3R-Gi complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | 登録日 | 2024-03-27 | 公開日 | 2024-06-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 11, 2024
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8YUV
| Cryo-EM structure of the immepip-bound H3R-Gi complex | 分子名称: | 4-(1H-imidazol-5-ylmethyl)piperidine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | 登録日 | 2024-03-27 | 公開日 | 2024-06-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 11, 2024
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8YUT
| Cryo-EM structure of the amthamine-bound H2R-Gs complex | 分子名称: | 5-(2-azanylethyl)-4-methyl-1,3-thiazol-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | 登録日 | 2024-03-27 | 公開日 | 2024-06-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 11, 2024
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8FY5
| Human TMEM175-LAMP1 full-length complex | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | 登録日 | 2023-01-25 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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8FYF
| Human TMEM175-LAMP1 transmembrane domain only complex | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | 登録日 | 2023-01-26 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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4ZA1
| Crystal Structure of NosA Involved in Nosiheptide Biosynthesis | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, NosA | 著者 | Liu, S, Guo, H, Zhang, T, Han, L, Yao, P, Zhang, Y, Rong, N, Yu, Y, Lan, W, Wang, C, Ding, J, Wang, R, Liu, W, Cao, C. | 登録日 | 2015-04-13 | 公開日 | 2015-08-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis Sci Rep, 5, 2015
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1IDS
| X-RAY STRUCTURE ANALYSIS OF THE IRON-DEPENDENT SUPEROXIDE DISMUTASE FROM MYCOBACTERIUM TUBERCULOSIS AT 2.0 ANGSTROMS RESOLUTIONS REVEALS NOVEL DIMER-DIMER INTERACTIONS | 分子名称: | FE (III) ION, IRON SUPEROXIDE DISMUTASE | 著者 | Cooper, J.B, Mcintyre, K, Wood, S.P, Zhang, Y, Young, D. | 登録日 | 1994-09-29 | 公開日 | 1994-12-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | X-ray structure analysis of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis at 2.0 Angstroms resolution reveals novel dimer-dimer interactions. J.Mol.Biol., 246, 1995
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2RFN
| x-ray structure of c-Met with inhibitor. | 分子名称: | 2-benzyl-5-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-methylpyrimidin-4(3H)-one, Hepatocyte growth factor receptor | 著者 | Bellon, S.F, Kaplan-Lefko, P, Yang, Y, Zhang, Y, Moriguchi, J, Dussault, I. | 登録日 | 2007-10-01 | 公開日 | 2007-11-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations. J.Biol.Chem., 283, 2008
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6PWX
| Cryo-EM structure of RbBP5 bound to the nucleosome | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | 登録日 | 2019-07-23 | 公開日 | 2019-12-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome. Nat Commun, 10, 2019
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6VP0
| Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Diacylglycerol O-acyltransferase 1, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Wang, L, Qian, H, Han, Y, Nian, Y, Ren, Z, Zhang, H, Hu, L, Prasad, B.V.V, Yan, N, Zhou, M. | 登録日 | 2020-02-01 | 公開日 | 2020-05-13 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature, 581, 2020
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6VUA
| X-ray structure of human CD38 catalytic domain with 2'-Cl-araNAD+ | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, DI(HYDROXYETHYL)ETHER, ... | 著者 | Dai, Z, Zhang, X.N, Nasertorabi, F, Han, G.W, Stevens, R.C, Zhang, Y. | 登録日 | 2020-02-14 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases. Sci Adv, 6, 2020
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8XOR
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