8FYF
Human TMEM175-LAMP1 transmembrane domain only complex
Summary for 8FYF
Entry DOI | 10.2210/pdb8fyf/pdb |
EMDB information | 29572 |
Descriptor | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 (2 entities in total) |
Functional Keywords | complex, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 201190.87 |
Authors | Zhang, J.Y.,Zeng, W.Z.,Han, Y.,Jiang, Y.X. (deposition date: 2023-01-26, release date: 2023-06-28, Last modification date: 2024-06-19) |
Primary citation | Zhang, J.,Zeng, W.,Han, Y.,Lee, W.R.,Liou, J.,Jiang, Y. Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83:2524-2539.e7, 2023 Cited by PubMed: 37390818DOI: 10.1016/j.molcel.2023.06.004 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
Download full validation report