6VUA

X-ray structure of human CD38 catalytic domain with 2'-Cl-araNAD+

Summary for 6VUA

• Entry DOI: 10.2210/pdb6vua/pdb
• Descriptor: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R})-4-chloranyl-3-oxidanyl-oxolan-2-yl]methyl hydrogen phosphate, POTASSIUM ION, ... (8 entities in total)
• Functional Keywords: inhibitor, cd38, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 61954.43

Authors

Dai, Z.,Zhang, X.N.,Nasertorabi, F.,Han, G.W.,Stevens, R.C.,Zhang, Y. (deposition date: 2020-02-14, release date: 2020-06-03, Last modification date: 2023-10-11)

• Primary citation: Dai, Z.,Zhang, X.N.,Nasertorabi, F.,Cheng, Q.,Li, J.,Katz, B.B.,Smbatyan, G.,Pei, H.,Louie, S.G.,Lenz, H.J.,Stevens, R.C.,Zhang, Y.; Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases.; Sci Adv, 6:eaba6752-eaba6752, 2020; PubMed: 32537509; DOI: 10.1126/sciadv.aba6752

Experimental method

X-RAY DIFFRACTION (1.5 Å)