8FY5
Human TMEM175-LAMP1 full-length complex
Summary for 8FY5
| Entry DOI | 10.2210/pdb8fy5/pdb |
| EMDB information | 29553 |
| Descriptor | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 (2 entities in total) |
| Functional Keywords | complex, membrane protein |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 201190.87 |
| Authors | Zhang, J.Y.,Zeng, W.Z.,Han, Y.,Jiang, Y.X. (deposition date: 2023-01-25, release date: 2023-06-28, Last modification date: 2023-08-02) |
| Primary citation | Zhang, J.,Zeng, W.,Han, Y.,Lee, W.R.,Liou, J.,Jiang, Y. Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83:2524-2539.e7, 2023 Cited by PubMed: 37390818DOI: 10.1016/j.molcel.2023.06.004 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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