4E8U
 
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4NGF
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4NGB
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4NH3
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4NHA
 | | Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 16-mer siRNA having 5'-p and UU-3' ends (3.4 Angstrom resolution) | | 分子名称: | 5'-R(P*GP*CP*GP*UP*UP*GP*GP*CP*CP*AP*AP*CP*GP*CP*UP*U)-3', Endoribonuclease Dicer | | 著者 | Simanshu, D.K, Tian, Y, Ma, J.-B, Patel, D.J. | | 登録日 | 2013-11-04 | | 公開日 | 2014-03-05 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.401 Å) | | 主引用文献 | A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Mol.Cell, 53, 2014
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4NGG
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4NGC
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4NH6
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7TVG
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7TVF
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6PQ3
 | | Crystal structure of GDP-bound KRAS with ten residues long internal tandem duplication in the switch II region | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Dharmaiah, S, Chan, A.H, Tran, T.H, Simanshu, D.K. | | 登録日 | 2019-07-08 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling.
J.Biol.Chem., 295, 2020
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5TAR
 | | Crystal structure of farnesylated and methylated kras4b in complex with PDE-delta (crystal form II - with ordered hypervariable region) | | 分子名称: | 1,2-ETHANEDIOL, FARNESYL, GTPase KRas, ... | | 著者 | Dharmaiah, S, Tran, T.H, Simanshu, D.K. | | 登録日 | 2016-09-10 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5TB5
 | | Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region) | | 分子名称: | 1,2-ETHANEDIOL, FARNESYL, GTPase KRas, ... | | 著者 | Dharmaiah, S, Tran, T.H, Simanshu, D.K. | | 登録日 | 2016-09-11 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.
Proc.Natl.Acad.Sci.USA, 113, 2016
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3O3I
 | | Crystal Structure of human Hiwi1 PAZ domain (residues 277-399) in complex with 14-mer RNA (12-bp + 2-nt overhang) containing 2'-OH at its 3'-end | | 分子名称: | Piwi-like protein 1, RNA (5'-R(*GP*CP*GP*AP*AP*UP*AP*UP*UP*CP*GP*CP*UP*U)-3') | | 著者 | Tian, Y, Simanshu, D.K, Ma, J.-B, Patel, D.J. | | 登録日 | 2010-07-24 | | 公開日 | 2011-01-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | | 主引用文献 | Inaugural Article: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
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8EBZ
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8EQ5
 | | Crystal structure of the N-terminal kinase domain of RSK2 in complex with SPRED2 (131-160) | | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, Ribosomal protein S6 kinase alpha-3, Sprouty-related, ... | | 著者 | Bonsor, D.A, Lopez, J, McCormick, F, Simanshu, D.K. | | 登録日 | 2022-10-07 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.
J.Biol.Chem., 299, 2023
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8EPW
 | | Crystal Structure of KRAS4b-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF | | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | | 登録日 | 2022-10-06 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D .
Commun Biol, 6, 2023
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6CU6
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2Z6R
 | | Crystal structure of Lys49 to Arg mutant of Diphthine synthase | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Mizutani, H, Matsuura, Y, Krishna Swamy, B.S, Simanshu, D.K, Murthy, M.R.N, Kunishima, N. | | 登録日 | 2007-08-08 | | 公開日 | 2007-08-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of diphthine synthase from Pyrococcus horikoshii OT3
To be Published
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6OB3
 | | Crystal structure of G13D-KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1) | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, GTPase KRas, ... | | 著者 | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | | 登録日 | 2019-03-19 | | 公開日 | 2019-10-16 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6OB2
 | | Crystal structure of wild-type KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1) | | 分子名称: | CHLORIDE ION, GLYCEROL, GTPase KRas, ... | | 著者 | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | | 登録日 | 2019-03-19 | | 公開日 | 2019-10-16 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.845 Å) | | 主引用文献 | KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6P0Z
 | | Crystal structure of N-acetylated KRAS (2-169) bound to GDP and Mg | | 分子名称: | ACETYL GROUP, DI(HYDROXYETHYL)ETHER, GTPase KRas, ... | | 著者 | Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. | | 登録日 | 2019-05-17 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.011 Å) | | 主引用文献 | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep, 9, 2019
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7LC2
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7LC1
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6MBT
 | | Crystal structure of wild-type KRAS bound to GDP and Mg (Space group C2) | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | 著者 | Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. | | 登録日 | 2018-08-30 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep, 9, 2019
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