6CU6

Crystal structure of GMPPNP-bound G12R mutant of human KRAS4b

Summary for 6CU6

Entry DOI	10.2210/pdb6cu6/pdb
Descriptor	GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
Functional Keywords	kras, ras, g12r, g12, kras4b, k-ras, oncoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	60018.46
Authors	Tran, T.H.,Simanshu, D.K. (deposition date: 2018-03-23, release date: 2019-09-25, Last modification date: 2024-04-03)
Primary citation	Hobbs, G.A.,Baker, N.M.,Miermont, A.M.,Thurman, R.D.,Pierobon, M.,Tran, T.H.,Anderson, A.O.,Waters, A.M.,Diehl, J.N.,Papke, B.,Hodge, R.G.,Klomp, J.E.,Goodwin, C.M.,DeLiberty, J.M.,Wang, J.,Ng, R.W.S.,Gautam, P.,Bryant, K.L.,Esposito, D.,Campbell, S.L.,Petricoin 3rd, E.F.,Simanshu, D.K.,Aguirre, A.J.,Wolpin, B.M.,Wennerberg, K.,Rudloff, U.,Cox, A.D.,Der, C.J. Atypical KRASG12RMutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discov, 10:104-123, 2020 Cited by PubMed: 31649109 DOI: 10.1158/2159-8290.CD-19-1006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation