6PQ3

Crystal structure of GDP-bound KRAS with ten residues long internal tandem duplication in the switch II region

Summary for 6PQ3

Entry DOI	10.2210/pdb6pq3/pdb
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	kras, ras, mg, k-ras, oncoprotein, gdp, internal tandem duplication, itd
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	21409.84
Authors	Dharmaiah, S.,Chan, A.H.,Tran, T.H.,Simanshu, D.K. (deposition date: 2019-07-08, release date: 2020-05-20, Last modification date: 2023-10-11)
Primary citation	Nelson, A.C.,Turbyville, T.J.,Dharmaiah, S.,Rigby, M.,Yang, R.,Wang, T.Y.,Columbus, J.,Stephens, R.,Taylor, T.,Sciacca, D.,Onsongo, G.,Sarver, A.,Subramanian, S.,Nissley, D.V.,Simanshu, D.K.,Lou, E. RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. J.Biol.Chem., 295:9335-9348, 2020 Cited by PubMed: 32393580 DOI: 10.1074/jbc.RA119.011080 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation