6PQ3
Crystal structure of GDP-bound KRAS with ten residues long internal tandem duplication in the switch II region
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue GDP A 201 |
| Chain | Residue |
| A | GLY13 |
| A | TYR32 |
| A | ASN126 |
| A | LYS127 |
| A | ASP129 |
| A | LEU130 |
| A | SER155 |
| A | ALA156 |
| A | LYS157 |
| A | MG202 |
| A | HOH305 |
| A | VAL14 |
| A | HOH310 |
| A | HOH315 |
| A | HOH320 |
| A | HOH321 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| A | ASP30 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | GDP201 |
| A | HOH305 |
| A | HOH310 |
| A | HOH315 |
| A | HOH318 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | ARG41 |
| A | ARG107 |
| A | GLU108 |
| A | LYS111 |
| A | GLU117 |
| A | TYR147 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 204 |
| Chain | Residue |
| A | HIS27 |
| A | PHE28 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 205 |
| Chain | Residue |
| A | THR97 |
| A | LYS98 |
| A | LYS98 |
| A | LYS98 |
| A | HOH303 |
| A | HOH303 |
| A | HOH303 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 206 |
| Chain | Residue |
| A | VAL45 |
| A | ILE46 |
| A | ASP47 |
| A | GLY48 |
| A | GLU62 |
| A | HIS105 |
| A | GLN109 |
| A | ARG112 |
| A | SO4207 |
| A | HOH323 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 207 |
| Chain | Residue |
| A | GLY60 |
| A | GLU62 |
| A | ILE65 |
| A | HIS105 |
| A | TYR106 |
| A | GLN109 |
| A | SO4206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
