4NHA
Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 16-mer siRNA having 5'-p and UU-3' ends (3.4 Angstrom resolution)
Summary for 4NHA
Entry DOI | 10.2210/pdb4nha/pdb |
Related | 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 |
Descriptor | Endoribonuclease Dicer, 5'-R(P*GP*CP*GP*UP*UP*GP*GP*CP*CP*AP*AP*CP*GP*CP*UP*U)-3' (2 entities in total) |
Functional Keywords | paz domain, platform domain, connector helix, sirna, rnase iii domain, endoribonuclease, pre-mirna, hydrolase-rna complex, hydrolase/rna |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q9UPY3 |
Total number of polymer chains | 2 |
Total formula weight | 40322.18 |
Authors | Simanshu, D.K.,Tian, Y.,Ma, J.-B.,Patel, D.J. (deposition date: 2013-11-04, release date: 2014-03-05, Last modification date: 2018-01-24) |
Primary citation | Tian, Y.,Simanshu, D.K.,Ma, J.B.,Park, J.E.,Heo, I.,Kim, V.N.,Patel, D.J. A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53:606-616, 2014 Cited by PubMed: 24486018DOI: 10.1016/j.molcel.2014.01.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.401 Å) |
Structure validation
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