7Z6O
 
 | | X-Ray studies of Ku70/80 reveal the binding site for IP6 | | 分子名称: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Varela, P.F, Charbonnier, J.B. | | 登録日 | 2022-03-14 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
|
|
5M05
 | | Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP form | | 分子名称: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Sirigu, S, Hartman, J, Houdusse, A. | | 登録日 | 2016-10-03 | | 公開日 | 2016-11-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.675 Å) | | 主引用文献 | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
|
|
5T45
 | | Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP.BeFx form | | 分子名称: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Sirigu, S, Planelles-Herrero, V.J, Hartman, J, Houdusse, A. | | 登録日 | 2016-08-29 | | 公開日 | 2016-11-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
|
|
4E7Z
 | | Myosin VI (MD) pre-powerstroke state, P21 crystal form | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Isabet, T, Sweeney, H.L, Houdusse, A. | | 登録日 | 2012-03-19 | | 公開日 | 2012-09-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI.
Mol.Cell, 48, 2012
|
|
4E7S
 | | Myosin VI D23R I24R R569E (MD) pre-powerstroke state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Isabet, T, Sweeney, H.L, Houdusse, A. | | 登録日 | 2012-03-19 | | 公開日 | 2012-09-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI.
Mol.Cell, 48, 2012
|
|
7NDY
 | | Di-phosphorylated Barrier-to-Autointegration Factor (BAF) in complex with LEM domain of Emerin | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Barrier-to-autointegration factor, N-terminally processed, ... | | 著者 | Marcelot, A, Le Du, M.H, Hoffmann, G, Zinn-Justin, S. | | 登録日 | 2021-02-02 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners.
Nucleic Acids Res., 49, 2021
|
|
7NFC
 | | Cryo-EM structure of NHEJ super-complex (dimer) | | 分子名称: | DNA (27-MER), DNA (28-MER), DNA ligase 4, ... | | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2021-02-05 | | 公開日 | 2021-08-18 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
|
|
7NFE
 | | Cryo-EM structure of NHEJ super-complex (monomer) | | 分子名称: | DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ... | | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | | 登録日 | 2021-02-06 | | 公開日 | 2021-08-18 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.29 Å) | | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
|
|
7NRN
 | | NMR structure of GIPC1-GH2 domain | | 分子名称: | PDZ domain-containing protein GIPC1 | | 著者 | Barthe, P, Roumestand, C. | | 登録日 | 2021-03-04 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Pressure and Chemical Unfolding of an alpha-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1.
Int J Mol Sci, 22, 2021
|
|
7ZT6
 | |
7ZVT
 | | CryoEM structure of Ku heterodimer bound to DNA | | 分子名称: | DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. | | 登録日 | 2022-05-17 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
|
|
4PK4
 | | Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | 登録日 | 2014-05-13 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
|
|
4PJK
 | | Dicty myosin II R238E.E459R mutant (with ADP.Pi) in the Pi release state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | 登録日 | 2014-05-12 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
|
|
4PFO
 | | Myosin VI motor domain in the Pi release state, space group P212121 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | 登録日 | 2014-04-30 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
|
|
4PJM
 | | Myosin VI motor domain in the Pi release state, space group P212121 - soaked with PO4 - located in the active site | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | 登録日 | 2014-05-12 | | 公開日 | 2015-04-29 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
|
|
4PFP
 | | Myosin VI motor domain in the Pi release state (with Pi) space group P21 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | 登録日 | 2014-04-30 | | 公開日 | 2015-04-29 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
|
|
4PJJ
 | | MYOSIN VI (MD-INSERT2-CAM, DELTA-INSERT1) post-rigor state - long soaking with PO4 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin, ... | | 著者 | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | 登録日 | 2014-05-12 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
|
|
4PJN
 | | Myosin VI motor domain in the Pi release state, space group P212121 - shortly soaked with PO4 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | 登録日 | 2014-05-12 | | 公開日 | 2015-04-29 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
|
|
4PJL
 | | Myosin VI motor domain A458E mutant in the Pi release state, space group P212121 - | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | 登録日 | 2014-05-12 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
|
|
7ZWA
 | | CryoEM structure of Ku heterodimer bound to DNA and PAXX | | 分子名称: | DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*T)-3'), PHOSPHATE ION, ... | | 著者 | Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. | | 登録日 | 2022-05-19 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
|
|
7ZYG
 | | CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF | | 分子名称: | DNA, Non-homologous end-joining factor 1, PHOSPHATE ION, ... | | 著者 | Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. | | 登録日 | 2022-05-24 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
|
|
8BOT
 | |
8BHV
 | |
8BHY
 | |
8BH3
 | |
