7ZVT

CryoEM structure of Ku heterodimer bound to DNA

Summary for 7ZVT

• Entry DOI: 10.2210/pdb7zvt/pdb
• EMDB information: 14986
• Descriptor: DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), X-ray repair cross-complementing protein 6, ... (5 entities in total)
• Functional Keywords: nhej, ku70, ku80, dna damage, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 162570.49

Authors

Hardwick, S.W.,Kefala-Stavridi, A.,Chirgadze, D.Y.,Blundell, T.L.,Chaplin, A.K. (deposition date: 2022-05-17, release date: 2023-05-24, Last modification date: 2023-12-06)

• Primary citation: Kefala Stavridi, A.,Gontier, A.,Morin, V.,Frit, P.,Ropars, V.,Barboule, N.,Racca, C.,Jonchhe, S.,Morten, M.J.,Andreani, J.,Rak, A.,Legrand, P.,Bourand-Plantefol, A.,Hardwick, S.W.,Chirgadze, D.Y.,Davey, P.,De Oliveira, T.M.,Rothenberg, E.,Britton, S.,Calsou, P.,Blundell, T.L.,Varela, P.F.,Chaplin, A.K.,Charbonnier, J.B.; Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.; Nucleic Acids Res., 51:11732-11747, 2023; PubMed: 37870477; DOI: 10.1093/nar/gkad863

Experimental method

ELECTRON MICROSCOPY (2.74 Å)