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7ZVT

CryoEM structure of Ku heterodimer bound to DNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000723biological_processtelomere maintenance
A0000725biological_processrecombinational repair
A0000781cellular_componentchromosome, telomeric region
A0000783cellular_componentnuclear telomere cap complex
A0000976molecular_functiontranscription cis-regulatory region binding
A0002218biological_processactivation of innate immune response
A0002376biological_processimmune system process
A0002684biological_processpositive regulation of immune system process
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003684molecular_functiondamaged DNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003691molecular_functiondouble-stranded telomeric DNA binding
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
A0006281biological_processDNA repair
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006310biological_processDNA recombination
A0006974biological_processDNA damage response
A0008094molecular_functionATP-dependent activity, acting on DNA
A0010212biological_processresponse to ionizing radiation
A0010558biological_processnegative regulation of macromolecule biosynthetic process
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016829molecular_functionlyase activity
A0016887molecular_functionATP hydrolysis activity
A0030332molecular_functioncyclin binding
A0032991cellular_componentprotein-containing complex
A0032993cellular_componentprotein-DNA complex
A0034774cellular_componentsecretory granule lumen
A0042162molecular_functiontelomeric DNA binding
A0043564cellular_componentKu70:Ku80 complex
A0044877molecular_functionprotein-containing complex binding
A0045027molecular_functionDNA end binding
A0045087biological_processinnate immune response
A0045621biological_processpositive regulation of lymphocyte differentiation
A0045860biological_processpositive regulation of protein kinase activity
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048660biological_processregulation of smooth muscle cell proliferation
A0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
A0070418cellular_componentDNA-dependent protein kinase complex
A0070419cellular_componentnonhomologous end joining complex
A0071475biological_processcellular hyperosmotic salinity response
A0071480biological_processcellular response to gamma radiation
A0071481biological_processcellular response to X-ray
A0097110molecular_functionscaffold protein binding
A0097680biological_processdouble-strand break repair via classical nonhomologous end joining
A1904813cellular_componentficolin-1-rich granule lumen
B0000166molecular_functionnucleotide binding
B0000723biological_processtelomere maintenance
B0000725biological_processrecombinational repair
B0000781cellular_componentchromosome, telomeric region
B0000783cellular_componentnuclear telomere cap complex
B0000976molecular_functiontranscription cis-regulatory region binding
B0002218biological_processactivation of innate immune response
B0002376biological_processimmune system process
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003684molecular_functiondamaged DNA binding
B0003690molecular_functiondouble-stranded DNA binding
B0003691molecular_functiondouble-stranded telomeric DNA binding
B0003723molecular_functionRNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
B0006281biological_processDNA repair
B0006302biological_processdouble-strand break repair
B0006303biological_processdouble-strand break repair via nonhomologous end joining
B0006310biological_processDNA recombination
B0006974biological_processDNA damage response
B0007004biological_processtelomere maintenance via telomerase
B0008047molecular_functionenzyme activator activity
B0008094molecular_functionATP-dependent activity, acting on DNA
B0010558biological_processnegative regulation of macromolecule biosynthetic process
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0022008biological_processneurogenesis
B0031625molecular_functionubiquitin protein ligase binding
B0032040cellular_componentsmall-subunit processome
B0032204biological_processregulation of telomere maintenance
B0032991cellular_componentprotein-containing complex
B0032993cellular_componentprotein-DNA complex
B0034462biological_processsmall-subunit processome assembly
B0034511molecular_functionU3 snoRNA binding
B0034774cellular_componentsecretory granule lumen
B0042162molecular_functiontelomeric DNA binding
B0042254biological_processribosome biogenesis
B0043564cellular_componentKu70:Ku80 complex
B0044877molecular_functionprotein-containing complex binding
B0045027molecular_functionDNA end binding
B0045087biological_processinnate immune response
B0045860biological_processpositive regulation of protein kinase activity
B0045892biological_processnegative regulation of DNA-templated transcription
B0048660biological_processregulation of smooth muscle cell proliferation
B0050769biological_processpositive regulation of neurogenesis
B0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
B0060218biological_processhematopoietic stem cell differentiation
B0070198biological_processprotein localization to chromosome, telomeric region
B0070418cellular_componentDNA-dependent protein kinase complex
B0070419cellular_componentnonhomologous end joining complex
B0071425biological_processhematopoietic stem cell proliferation
B0071480biological_processcellular response to gamma radiation
B0090734cellular_componentsite of DNA damage
B1904430biological_processnegative regulation of t-circle formation
B1990830biological_processcellular response to leukemia inhibitory factor
B1990904cellular_componentribonucleoprotein complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues109
DetailsRegion: {"description":"Interaction with XRCC5","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"9362500","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues7
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues199
DetailsDomain: {"description":"Ku","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues27
DetailsRegion: {"description":"Leucine-zipper"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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