7NFC

Cryo-EM structure of NHEJ super-complex (dimer)

Summary for 7NFC

Entry DOI	10.2210/pdb7nfc/pdb
EMDB information	12299
Descriptor	DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 5, ... (9 entities in total)
Functional Keywords	nhej, dna-pkcs, ku70/80, xlf, xrcc4, dna-ligaseiv, dna binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	18
Total formula weight	1710536.03
Authors	Chaplin, A.K.,Hardwick, S.W.,Kefala Stavridi, A.,Chirgadze, D.Y.,Blundell, T.L. (deposition date: 2021-02-05, release date: 2021-08-18, Last modification date: 2021-09-22)
Primary citation	Chaplin, A.K.,Hardwick, S.W.,Stavridi, A.K.,Buehl, C.J.,Goff, N.J.,Ropars, V.,Liang, S.,De Oliveira, T.M.,Chirgadze, D.Y.,Meek, K.,Charbonnier, J.B.,Blundell, T.L. Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81:3400-, 2021 Cited by PubMed: 34352203 DOI: 10.1016/j.molcel.2021.07.005 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.14 Å)

Structure validation