7NFC
Cryo-EM structure of NHEJ super-complex (dimer)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F | DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs | polymer | 4148 | 471375.4 | 2 | UniProt (P78527) Pfam (PF20502) Pfam (PF08163) Pfam (PF19704) Pfam (PF02259) Pfam (PF00454) Pfam (PF02260) In PDB | Homo sapiens (Human) | DNA-PK catalytic subunit,DNA-PKcs,DNPK1,p460 |
| 2 | B, G | X-ray repair cross-complementing protein 6 | polymer | 609 | 69945.0 | 2 | UniProt (P12956) Pfam (PF02037) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) In PDB | Homo sapiens (Human) | 5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTCBF,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Ku70,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 6 |
| 3 | C, H | X-ray repair cross-complementing protein 5 | polymer | 732 | 82812.4 | 2 | UniProt (P13010) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF08785) In PDB | Homo sapiens (Human) | 86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTCBF,DNA repair protein XRCC5,Ku80,Ku86,Lupus Ku autoantigen protein p86,Nuclear factor IV,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) |
| 4 | K, L, N, O | DNA repair protein XRCC4 | polymer | 336 | 38337.7 | 4 | UniProt (Q13426) Pfam (PF06632) Pfam (PF21924) Pfam (PF21925) In PDB | Homo sapiens (Human) | X-ray repair cross-complementing protein 4 |
| 5 | M, P | DNA ligase 4 | polymer | 911 | 104125.0 | 2 | UniProt (P49917) Pfam (PF04675) Pfam (PF01068) Pfam (PF04679) Pfam (PF00533) Pfam (PF11411) In PDB | Homo sapiens (Human) | DNA ligase IV,Polydeoxyribonucleotide synthase [ATP] 4 |
| 6 | Q, R | Non-homologous end-joining factor 1 | polymer | 299 | 33372.2 | 2 | UniProt (Q9H9Q4) Pfam (PF09302) Pfam (PF21928) In PDB | Homo sapiens (Human) | Protein cernunnos,XRCC4-like factor |
| 7 | D | DNA (27-MER) | polymer | 27 | 8335.4 | 1 | Homo sapiens | ||
| 8 | E, I | DNA (28-MER) | polymer | 28 | 8619.6 | 2 | Homo sapiens | ||
| 9 | J | DNA (27-MER) | polymer | 27 | 8350.4 | 1 | Homo sapiens |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 1710536.0 | |
| All* | Total formula weight | 1710536.0 |
