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7NFC

Cryo-EM structure of NHEJ super-complex (dimer)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000460biological_processmaturation of 5.8S rRNA
A0000723biological_processtelomere maintenance
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0001756biological_processsomitogenesis
A0001933biological_processnegative regulation of protein phosphorylation
A0002218biological_processactivation of innate immune response
A0002326biological_processB cell lineage commitment
A0002327biological_processimmature B cell differentiation
A0002328biological_processpro-B cell differentiation
A0002360biological_processT cell lineage commitment
A0003677molecular_functionDNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003723molecular_functionRNA binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005730cellular_componentnucleolus
A0005829cellular_componentcytosol
A0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006310biological_processDNA recombination
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006974biological_processDNA damage response
A0007420biological_processbrain development
A0007507biological_processheart development
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010212biological_processresponse to ionizing radiation
A0010332biological_processresponse to gamma radiation
A0016020cellular_componentmembrane
A0016233biological_processtelomere capping
A0016301molecular_functionkinase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0030098biological_processlymphocyte differentiation
A0031571biological_processmitotic G1 DNA damage checkpoint signaling
A0031648biological_processprotein destabilization
A0032040cellular_componentsmall-subunit processome
A0032869biological_processcellular response to insulin stimulus
A0032991cellular_componentprotein-containing complex
A0032993cellular_componentprotein-DNA complex
A0033077biological_processT cell differentiation in thymus
A0033151biological_processV(D)J recombination
A0033152biological_processimmunoglobulin V(D)J recombination
A0033153biological_processT cell receptor V(D)J recombination
A0034462biological_processsmall-subunit processome assembly
A0034511molecular_functionU3 snoRNA binding
A0035234biological_processectopic germ cell programmed cell death
A0035979molecular_functionhistone H2AXS139 kinase activity
A0036211biological_processprotein modification process
A0042254biological_processribosome biogenesis
A0042752biological_processregulation of circadian rhythm
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0045087biological_processinnate immune response
A0045621biological_processpositive regulation of lymphocyte differentiation
A0045648biological_processpositive regulation of erythrocyte differentiation
A0045727biological_processpositive regulation of translation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048511biological_processrhythmic process
A0048660biological_processregulation of smooth muscle cell proliferation
A0050678biological_processregulation of epithelial cell proliferation
A0060255biological_processregulation of macromolecule metabolic process
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070418cellular_componentDNA-dependent protein kinase complex
A0070419cellular_componentnonhomologous end joining complex
A0080090biological_processregulation of primary metabolic process
A0080135biological_processregulation of cellular response to stress
A0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
A0106310molecular_functionprotein serine kinase activity
A0160049biological_processnegative regulation of cGAS/STING signaling pathway
A1902036biological_processregulation of hematopoietic stem cell differentiation
A1905221biological_processpositive regulation of platelet formation
A2001034biological_processpositive regulation of double-strand break repair via nonhomologous end joining
B0000723biological_processtelomere maintenance
B0000725biological_processrecombinational repair
B0000781cellular_componentchromosome, telomeric region
B0000783cellular_componentnuclear telomere cap complex
B0000976molecular_functiontranscription cis-regulatory region binding
B0002218biological_processactivation of innate immune response
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003684molecular_functiondamaged DNA binding
B0003690molecular_functiondouble-stranded DNA binding
B0003691molecular_functiondouble-stranded telomeric DNA binding
B0003723molecular_functionRNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005667cellular_componenttranscription regulator complex
B0005694cellular_componentchromosome
B0005730cellular_componentnucleolus
B0005829cellular_componentcytosol
B0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
B0006266biological_processDNA ligation
B0006281biological_processDNA repair
B0006303biological_processdouble-strand break repair via nonhomologous end joining
B0006310biological_processDNA recombination
B0008094molecular_functionATP-dependent activity, acting on DNA
B0010558biological_processnegative regulation of macromolecule biosynthetic process
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016829molecular_functionlyase activity
B0016887molecular_functionATP hydrolysis activity
B0030332molecular_functioncyclin binding
B0032508biological_processDNA duplex unwinding
B0032991cellular_componentprotein-containing complex
B0032993cellular_componentprotein-DNA complex
B0034774cellular_componentsecretory granule lumen
B0042162molecular_functiontelomeric DNA binding
B0043564cellular_componentKu70:Ku80 complex
B0044877molecular_functionprotein-containing complex binding
B0045027molecular_functionDNA end binding
B0045087biological_processinnate immune response
B0045621biological_processpositive regulation of lymphocyte differentiation
B0045860biological_processpositive regulation of protein kinase activity
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048660biological_processregulation of smooth muscle cell proliferation
B0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
B0070418cellular_componentDNA-dependent protein kinase complex
B0070419cellular_componentnonhomologous end joining complex
B0071475biological_processcellular hyperosmotic salinity response
B0071480biological_processcellular response to gamma radiation
B0071481biological_processcellular response to X-ray
B0097110molecular_functionscaffold protein binding
B0097680biological_processdouble-strand break repair via classical nonhomologous end joining
B1904813cellular_componentficolin-1-rich granule lumen
C0000723biological_processtelomere maintenance
C0000725biological_processrecombinational repair
C0000781cellular_componentchromosome, telomeric region
C0000783cellular_componentnuclear telomere cap complex
C0000976molecular_functiontranscription cis-regulatory region binding
C0002218biological_processactivation of innate immune response
C0003677molecular_functionDNA binding
C0003678molecular_functionDNA helicase activity
C0003684molecular_functiondamaged DNA binding
C0003690molecular_functiondouble-stranded DNA binding
C0003691molecular_functiondouble-stranded telomeric DNA binding
C0003723molecular_functionRNA binding
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
C0006281biological_processDNA repair
C0006302biological_processdouble-strand break repair
C0006303biological_processdouble-strand break repair via nonhomologous end joining
C0006310biological_processDNA recombination
C0006974biological_processDNA damage response
C0008047molecular_functionenzyme activator activity
C0008094molecular_functionATP-dependent activity, acting on DNA
C0009410biological_processresponse to xenobiotic stimulus
C0010558biological_processnegative regulation of macromolecule biosynthetic process
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0022008biological_processneurogenesis
C0031625molecular_functionubiquitin protein ligase binding
C0032040cellular_componentsmall-subunit processome
C0032204biological_processregulation of telomere maintenance
C0032212biological_processpositive regulation of telomere maintenance via telomerase
C0032508biological_processDNA duplex unwinding
C0032991cellular_componentprotein-containing complex
C0032993cellular_componentprotein-DNA complex
C0034462biological_processsmall-subunit processome assembly
C0034511molecular_functionU3 snoRNA binding
C0034774cellular_componentsecretory granule lumen
C0042162molecular_functiontelomeric DNA binding
C0042254biological_processribosome biogenesis
C0043085biological_processpositive regulation of catalytic activity
C0043564cellular_componentKu70:Ku80 complex
C0044877molecular_functionprotein-containing complex binding
C0045027molecular_functionDNA end binding
C0045087biological_processinnate immune response
C0045860biological_processpositive regulation of protein kinase activity
C0045892biological_processnegative regulation of DNA-templated transcription
C0048660biological_processregulation of smooth muscle cell proliferation
C0050769biological_processpositive regulation of neurogenesis
C0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
C0051973biological_processpositive regulation of telomerase activity
C0060218biological_processhematopoietic stem cell differentiation
C0070198biological_processprotein localization to chromosome, telomeric region
C0070418cellular_componentDNA-dependent protein kinase complex
C0070419cellular_componentnonhomologous end joining complex
C0071398biological_processcellular response to fatty acid
C0071425biological_processhematopoietic stem cell proliferation
C0071475biological_processcellular hyperosmotic salinity response
C0071480biological_processcellular response to gamma radiation
C0071481biological_processcellular response to X-ray
C0090734cellular_componentsite of DNA damage
C1904430biological_processnegative regulation of t-circle formation
C1990830biological_processcellular response to leukemia inhibitory factor
C1990904cellular_componentribonucleoprotein complex
F0000460biological_processmaturation of 5.8S rRNA
F0000723biological_processtelomere maintenance
F0000781cellular_componentchromosome, telomeric region
F0000785cellular_componentchromatin
F0001756biological_processsomitogenesis
F0001933biological_processnegative regulation of protein phosphorylation
F0002218biological_processactivation of innate immune response
F0002326biological_processB cell lineage commitment
F0002327biological_processimmature B cell differentiation
F0002328biological_processpro-B cell differentiation
F0002360biological_processT cell lineage commitment
F0003677molecular_functionDNA binding
F0003690molecular_functiondouble-stranded DNA binding
F0003723molecular_functionRNA binding
F0004672molecular_functionprotein kinase activity
F0004674molecular_functionprotein serine/threonine kinase activity
F0004677molecular_functionDNA-dependent protein kinase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005667cellular_componenttranscription regulator complex
F0005730cellular_componentnucleolus
F0005829cellular_componentcytosol
F0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
F0006281biological_processDNA repair
F0006302biological_processdouble-strand break repair
F0006303biological_processdouble-strand break repair via nonhomologous end joining
F0006310biological_processDNA recombination
F0006338biological_processchromatin remodeling
F0006468biological_processprotein phosphorylation
F0006974biological_processDNA damage response
F0007420biological_processbrain development
F0007507biological_processheart development
F0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
F0010212biological_processresponse to ionizing radiation
F0010332biological_processresponse to gamma radiation
F0016020cellular_componentmembrane
F0016233biological_processtelomere capping
F0016301molecular_functionkinase activity
F0018105biological_processpeptidyl-serine phosphorylation
F0018107biological_processpeptidyl-threonine phosphorylation
F0019899molecular_functionenzyme binding
F0019904molecular_functionprotein domain specific binding
F0030098biological_processlymphocyte differentiation
F0031571biological_processmitotic G1 DNA damage checkpoint signaling
F0031648biological_processprotein destabilization
F0032040cellular_componentsmall-subunit processome
F0032869biological_processcellular response to insulin stimulus
F0032991cellular_componentprotein-containing complex
F0032993cellular_componentprotein-DNA complex
F0033077biological_processT cell differentiation in thymus
F0033151biological_processV(D)J recombination
F0033152biological_processimmunoglobulin V(D)J recombination
F0033153biological_processT cell receptor V(D)J recombination
F0034462biological_processsmall-subunit processome assembly
F0034511molecular_functionU3 snoRNA binding
F0035234biological_processectopic germ cell programmed cell death
F0035979molecular_functionhistone H2AXS139 kinase activity
F0036211biological_processprotein modification process
F0042254biological_processribosome biogenesis
F0042752biological_processregulation of circadian rhythm
F0043065biological_processpositive regulation of apoptotic process
F0043066biological_processnegative regulation of apoptotic process
F0045087biological_processinnate immune response
F0045621biological_processpositive regulation of lymphocyte differentiation
F0045648biological_processpositive regulation of erythrocyte differentiation
F0045727biological_processpositive regulation of translation
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0048511biological_processrhythmic process
F0048660biological_processregulation of smooth muscle cell proliferation
F0050678biological_processregulation of epithelial cell proliferation
F0060255biological_processregulation of macromolecule metabolic process
F0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
F0070418cellular_componentDNA-dependent protein kinase complex
F0070419cellular_componentnonhomologous end joining complex
F0080090biological_processregulation of primary metabolic process
F0080135biological_processregulation of cellular response to stress
F0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
F0106310molecular_functionprotein serine kinase activity
F0160049biological_processnegative regulation of cGAS/STING signaling pathway
F1902036biological_processregulation of hematopoietic stem cell differentiation
F1905221biological_processpositive regulation of platelet formation
F2001034biological_processpositive regulation of double-strand break repair via nonhomologous end joining
G0000723biological_processtelomere maintenance
G0000725biological_processrecombinational repair
G0000781cellular_componentchromosome, telomeric region
G0000783cellular_componentnuclear telomere cap complex
G0000976molecular_functiontranscription cis-regulatory region binding
G0002218biological_processactivation of innate immune response
G0003677molecular_functionDNA binding
G0003678molecular_functionDNA helicase activity
G0003684molecular_functiondamaged DNA binding
G0003690molecular_functiondouble-stranded DNA binding
G0003691molecular_functiondouble-stranded telomeric DNA binding
G0003723molecular_functionRNA binding
G0004386molecular_functionhelicase activity
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005667cellular_componenttranscription regulator complex
G0005694cellular_componentchromosome
G0005730cellular_componentnucleolus
G0005829cellular_componentcytosol
G0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
G0006266biological_processDNA ligation
G0006281biological_processDNA repair
G0006303biological_processdouble-strand break repair via nonhomologous end joining
G0006310biological_processDNA recombination
G0008094molecular_functionATP-dependent activity, acting on DNA
G0010558biological_processnegative regulation of macromolecule biosynthetic process
G0016020cellular_componentmembrane
G0016787molecular_functionhydrolase activity
G0016829molecular_functionlyase activity
G0016887molecular_functionATP hydrolysis activity
G0030332molecular_functioncyclin binding
G0032508biological_processDNA duplex unwinding
G0032991cellular_componentprotein-containing complex
G0032993cellular_componentprotein-DNA complex
G0034774cellular_componentsecretory granule lumen
G0042162molecular_functiontelomeric DNA binding
G0043564cellular_componentKu70:Ku80 complex
G0044877molecular_functionprotein-containing complex binding
G0045027molecular_functionDNA end binding
G0045087biological_processinnate immune response
G0045621biological_processpositive regulation of lymphocyte differentiation
G0045860biological_processpositive regulation of protein kinase activity
G0045892biological_processnegative regulation of DNA-templated transcription
G0045893biological_processpositive regulation of DNA-templated transcription
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0048660biological_processregulation of smooth muscle cell proliferation
G0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
G0070418cellular_componentDNA-dependent protein kinase complex
G0070419cellular_componentnonhomologous end joining complex
G0071475biological_processcellular hyperosmotic salinity response
G0071480biological_processcellular response to gamma radiation
G0071481biological_processcellular response to X-ray
G0097110molecular_functionscaffold protein binding
G0097680biological_processdouble-strand break repair via classical nonhomologous end joining
G1904813cellular_componentficolin-1-rich granule lumen
H0000723biological_processtelomere maintenance
H0000725biological_processrecombinational repair
H0000781cellular_componentchromosome, telomeric region
H0000783cellular_componentnuclear telomere cap complex
H0000976molecular_functiontranscription cis-regulatory region binding
H0002218biological_processactivation of innate immune response
H0003677molecular_functionDNA binding
H0003678molecular_functionDNA helicase activity
H0003684molecular_functiondamaged DNA binding
H0003690molecular_functiondouble-stranded DNA binding
H0003691molecular_functiondouble-stranded telomeric DNA binding
H0003723molecular_functionRNA binding
H0004386molecular_functionhelicase activity
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005694cellular_componentchromosome
H0005730cellular_componentnucleolus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
H0006281biological_processDNA repair
H0006302biological_processdouble-strand break repair
H0006303biological_processdouble-strand break repair via nonhomologous end joining
H0006310biological_processDNA recombination
H0006974biological_processDNA damage response
H0008047molecular_functionenzyme activator activity
H0008094molecular_functionATP-dependent activity, acting on DNA
H0009410biological_processresponse to xenobiotic stimulus
H0010558biological_processnegative regulation of macromolecule biosynthetic process
H0016020cellular_componentmembrane
H0016787molecular_functionhydrolase activity
H0016887molecular_functionATP hydrolysis activity
H0022008biological_processneurogenesis
H0031625molecular_functionubiquitin protein ligase binding
H0032040cellular_componentsmall-subunit processome
H0032204biological_processregulation of telomere maintenance
H0032212biological_processpositive regulation of telomere maintenance via telomerase
H0032508biological_processDNA duplex unwinding
H0032991cellular_componentprotein-containing complex
H0032993cellular_componentprotein-DNA complex
H0034462biological_processsmall-subunit processome assembly
H0034511molecular_functionU3 snoRNA binding
H0034774cellular_componentsecretory granule lumen
H0042162molecular_functiontelomeric DNA binding
H0042254biological_processribosome biogenesis
H0043085biological_processpositive regulation of catalytic activity
H0043564cellular_componentKu70:Ku80 complex
H0044877molecular_functionprotein-containing complex binding
H0045027molecular_functionDNA end binding
H0045087biological_processinnate immune response
H0045860biological_processpositive regulation of protein kinase activity
H0045892biological_processnegative regulation of DNA-templated transcription
H0048660biological_processregulation of smooth muscle cell proliferation
H0050769biological_processpositive regulation of neurogenesis
H0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
H0051973biological_processpositive regulation of telomerase activity
H0060218biological_processhematopoietic stem cell differentiation
H0070198biological_processprotein localization to chromosome, telomeric region
H0070418cellular_componentDNA-dependent protein kinase complex
H0070419cellular_componentnonhomologous end joining complex
H0071398biological_processcellular response to fatty acid
H0071425biological_processhematopoietic stem cell proliferation
H0071475biological_processcellular hyperosmotic salinity response
H0071480biological_processcellular response to gamma radiation
H0071481biological_processcellular response to X-ray
H0090734cellular_componentsite of DNA damage
H1904430biological_processnegative regulation of t-circle formation
H1990830biological_processcellular response to leukemia inhibitory factor
H1990904cellular_componentribonucleoprotein complex
K0000793cellular_componentcondensed chromosome
K0003677molecular_functionDNA binding
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005694cellular_componentchromosome
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
K0006281biological_processDNA repair
K0006302biological_processdouble-strand break repair
K0006303biological_processdouble-strand break repair via nonhomologous end joining
K0006310biological_processDNA recombination
K0010165biological_processresponse to X-ray
K0016874molecular_functionligase activity
K0032807cellular_componentDNA ligase IV complex
K0033152biological_processimmunoglobulin V(D)J recombination
K0035861cellular_componentsite of double-strand break
K0042802molecular_functionidentical protein binding
K0051103biological_processDNA ligation involved in DNA repair
K0051351biological_processpositive regulation of ligase activity
K0070419cellular_componentnonhomologous end joining complex
K0070975molecular_functionFHA domain binding
K0071285biological_processcellular response to lithium ion
K1990166biological_processprotein localization to site of double-strand break
L0000793cellular_componentcondensed chromosome
L0003677molecular_functionDNA binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005694cellular_componentchromosome
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
L0006281biological_processDNA repair
L0006302biological_processdouble-strand break repair
L0006303biological_processdouble-strand break repair via nonhomologous end joining
L0006310biological_processDNA recombination
L0010165biological_processresponse to X-ray
L0016874molecular_functionligase activity
L0032807cellular_componentDNA ligase IV complex
L0033152biological_processimmunoglobulin V(D)J recombination
L0035861cellular_componentsite of double-strand break
L0042802molecular_functionidentical protein binding
L0051103biological_processDNA ligation involved in DNA repair
L0051351biological_processpositive regulation of ligase activity
L0070419cellular_componentnonhomologous end joining complex
L0070975molecular_functionFHA domain binding
L0071285biological_processcellular response to lithium ion
L1990166biological_processprotein localization to site of double-strand break
M0000012biological_processsingle strand break repair
M0000287molecular_functionmagnesium ion binding
M0000781cellular_componentchromosome, telomeric region
M0000793cellular_componentcondensed chromosome
M0001701biological_processin utero embryonic development
M0002328biological_processpro-B cell differentiation
M0003677molecular_functionDNA binding
M0003909molecular_functionDNA ligase activity
M0003910molecular_functionDNA ligase (ATP) activity
M0005515molecular_functionprotein binding
M0005524molecular_functionATP binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
M0006266biological_processDNA ligation
M0006281biological_processDNA repair
M0006297biological_processnucleotide-excision repair, DNA gap filling
M0006302biological_processdouble-strand break repair
M0006303biological_processdouble-strand break repair via nonhomologous end joining
M0006310biological_processDNA recombination
M0007417biological_processcentral nervous system development
M0008283biological_processcell population proliferation
M0010165biological_processresponse to X-ray
M0010212biological_processresponse to ionizing radiation
M0010332biological_processresponse to gamma radiation
M0016874molecular_functionligase activity
M0022008biological_processneurogenesis
M0032807cellular_componentDNA ligase IV complex
M0033077biological_processT cell differentiation in thymus
M0033151biological_processV(D)J recombination
M0033152biological_processimmunoglobulin V(D)J recombination
M0033153biological_processT cell receptor V(D)J recombination
M0035019biological_processsomatic stem cell population maintenance
M0043231cellular_componentintracellular membrane-bounded organelle
M0043524biological_processnegative regulation of neuron apoptotic process
M0045190biological_processisotype switching
M0046872molecular_functionmetal ion binding
M0048144biological_processfibroblast proliferation
M0048146biological_processpositive regulation of fibroblast proliferation
M0050769biological_processpositive regulation of neurogenesis
M0051102biological_processDNA ligation involved in DNA recombination
M0051103biological_processDNA ligation involved in DNA repair
M0051276biological_processchromosome organization
M0051301biological_processcell division
M0051402biological_processneuron apoptotic process
M0070419cellular_componentnonhomologous end joining complex
M0071285biological_processcellular response to lithium ion
M0071479biological_processcellular response to ionizing radiation
M0071897biological_processDNA biosynthetic process
M0072089biological_processstem cell proliferation
M0075713biological_processestablishment of integrated proviral latency
M0097680biological_processdouble-strand break repair via classical nonhomologous end joining
M1904155biological_processDN2 thymocyte differentiation
M2001252biological_processpositive regulation of chromosome organization
N0000793cellular_componentcondensed chromosome
N0003677molecular_functionDNA binding
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005694cellular_componentchromosome
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
N0006281biological_processDNA repair
N0006302biological_processdouble-strand break repair
N0006303biological_processdouble-strand break repair via nonhomologous end joining
N0006310biological_processDNA recombination
N0010165biological_processresponse to X-ray
N0016874molecular_functionligase activity
N0032807cellular_componentDNA ligase IV complex
N0033152biological_processimmunoglobulin V(D)J recombination
N0035861cellular_componentsite of double-strand break
N0042802molecular_functionidentical protein binding
N0051103biological_processDNA ligation involved in DNA repair
N0051351biological_processpositive regulation of ligase activity
N0070419cellular_componentnonhomologous end joining complex
N0070975molecular_functionFHA domain binding
N0071285biological_processcellular response to lithium ion
N1990166biological_processprotein localization to site of double-strand break
O0000793cellular_componentcondensed chromosome
O0003677molecular_functionDNA binding
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005694cellular_componentchromosome
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
O0006281biological_processDNA repair
O0006302biological_processdouble-strand break repair
O0006303biological_processdouble-strand break repair via nonhomologous end joining
O0006310biological_processDNA recombination
O0010165biological_processresponse to X-ray
O0016874molecular_functionligase activity
O0032807cellular_componentDNA ligase IV complex
O0033152biological_processimmunoglobulin V(D)J recombination
O0035861cellular_componentsite of double-strand break
O0042802molecular_functionidentical protein binding
O0051103biological_processDNA ligation involved in DNA repair
O0051351biological_processpositive regulation of ligase activity
O0070419cellular_componentnonhomologous end joining complex
O0070975molecular_functionFHA domain binding
O0071285biological_processcellular response to lithium ion
O1990166biological_processprotein localization to site of double-strand break
P0000012biological_processsingle strand break repair
P0000287molecular_functionmagnesium ion binding
P0000781cellular_componentchromosome, telomeric region
P0000793cellular_componentcondensed chromosome
P0001701biological_processin utero embryonic development
P0002328biological_processpro-B cell differentiation
P0003677molecular_functionDNA binding
P0003909molecular_functionDNA ligase activity
P0003910molecular_functionDNA ligase (ATP) activity
P0005515molecular_functionprotein binding
P0005524molecular_functionATP binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
P0006266biological_processDNA ligation
P0006281biological_processDNA repair
P0006297biological_processnucleotide-excision repair, DNA gap filling
P0006302biological_processdouble-strand break repair
P0006303biological_processdouble-strand break repair via nonhomologous end joining
P0006310biological_processDNA recombination
P0007417biological_processcentral nervous system development
P0008283biological_processcell population proliferation
P0010165biological_processresponse to X-ray
P0010212biological_processresponse to ionizing radiation
P0010332biological_processresponse to gamma radiation
P0016874molecular_functionligase activity
P0022008biological_processneurogenesis
P0032807cellular_componentDNA ligase IV complex
P0033077biological_processT cell differentiation in thymus
P0033151biological_processV(D)J recombination
P0033152biological_processimmunoglobulin V(D)J recombination
P0033153biological_processT cell receptor V(D)J recombination
P0035019biological_processsomatic stem cell population maintenance
P0043231cellular_componentintracellular membrane-bounded organelle
P0043524biological_processnegative regulation of neuron apoptotic process
P0045190biological_processisotype switching
P0046872molecular_functionmetal ion binding
P0048144biological_processfibroblast proliferation
P0048146biological_processpositive regulation of fibroblast proliferation
P0050769biological_processpositive regulation of neurogenesis
P0051102biological_processDNA ligation involved in DNA recombination
P0051103biological_processDNA ligation involved in DNA repair
P0051276biological_processchromosome organization
P0051301biological_processcell division
P0051402biological_processneuron apoptotic process
P0070419cellular_componentnonhomologous end joining complex
P0071285biological_processcellular response to lithium ion
P0071479biological_processcellular response to ionizing radiation
P0071897biological_processDNA biosynthetic process
P0072089biological_processstem cell proliferation
P0075713biological_processestablishment of integrated proviral latency
P0097680biological_processdouble-strand break repair via classical nonhomologous end joining
P1904155biological_processDN2 thymocyte differentiation
P2001252biological_processpositive regulation of chromosome organization
Q0001650cellular_componentfibrillar center
Q0003677molecular_functionDNA binding
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005694cellular_componentchromosome
Q0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
Q0006281biological_processDNA repair
Q0006302biological_processdouble-strand break repair
Q0006303biological_processdouble-strand break repair via nonhomologous end joining
Q0007417biological_processcentral nervous system development
Q0010212biological_processresponse to ionizing radiation
Q0030183biological_processB cell differentiation
Q0030217biological_processT cell differentiation
Q0032807cellular_componentDNA ligase IV complex
Q0033152biological_processimmunoglobulin V(D)J recombination
Q0035861cellular_componentsite of double-strand break
Q0045027molecular_functionDNA end binding
Q0051103biological_processDNA ligation involved in DNA repair
Q0051351biological_processpositive regulation of ligase activity
Q0070182molecular_functionDNA polymerase binding
Q0070419cellular_componentnonhomologous end joining complex
R0001650cellular_componentfibrillar center
R0003677molecular_functionDNA binding
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005694cellular_componentchromosome
R0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
R0006281biological_processDNA repair
R0006302biological_processdouble-strand break repair
R0006303biological_processdouble-strand break repair via nonhomologous end joining
R0007417biological_processcentral nervous system development
R0010212biological_processresponse to ionizing radiation
R0030183biological_processB cell differentiation
R0030217biological_processT cell differentiation
R0032807cellular_componentDNA ligase IV complex
R0033152biological_processimmunoglobulin V(D)J recombination
R0035861cellular_componentsite of double-strand break
R0045027molecular_functionDNA end binding
R0051103biological_processDNA ligation involved in DNA repair
R0051351biological_processpositive regulation of ligase activity
R0070182molecular_functionDNA polymerase binding
R0070419cellular_componentnonhomologous end joining complex
Functional Information from PROSITE/UniProt
site_idPS00333
Number of Residues25
DetailsDNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGIMVKqplsi...YKpdk...RgegwlKIK
ChainResidueDetails
MGLU427-LYS451

site_idPS00697
Number of Residues9
DetailsDNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. ETKLDGERM
ChainResidueDetails
MGLU271-MET279

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ
ChainResidueDetails
AVAL3752-GLN3766

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN
ChainResidueDetails
ASER3907-ASN3927

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Leu-lock => ECO:0000303|PubMed:21775435
ChainResidueDetails
QLEU115
HLYS665
RLEU115
NASP265
OASP265
CLYS665
HLYS144
HLYS265
HLYS332
HLYS660

site_idSWS_FT_FI2
Number of Residues8
DetailsMOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754
ChainResidueDetails
QSER132
ALYS3642
FLYS117
FLYS828
FLYS1209
FLYS1970
FLYS2259
FLYS3241
FLYS3260
FLYS3621
FLYS3638
QSER203
FLYS3642
QSER245
QSER251
RSER132
RSER203
RSER245
RSER251
ALYS3638

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:22228831
ChainResidueDetails
QSER263
PLYS451
FSER1065
FSER2789
FSER3731
FSER3821
RSER263
MLEU274
MLYS449
MLYS451
PTHR272
PLYS273
PLEU274
PLYS449

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:22228831
ChainResidueDetails
QTHR266
RTHR266
MPHE367
MLYS432
PARG278
PLYS345
PPHE367
PLYS432

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
QSER287
RSER287
PGLU331
PGLU427

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:28453785, ECO:0007744|PubMed:24275569
ChainResidueDetails
KTHR233
LTHR233
NTHR233
OTHR233

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
KSER237
LSER237
NSER237
OSER237

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
KSER256
HLYS532
HLYS534
HLYS566
HLYS669
HLYS688
LSER256
NSER256
OSER256
CLYS566
CLYS669
CLYS688
HLYS195

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30247612, ECO:0007744|PubMed:23186163
ChainResidueDetails
KSER260
LSER260
NSER260
OSER260

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831
ChainResidueDetails
KSER303
LSER303
NSER303
OSER303

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:23186163
ChainResidueDetails
KSER304
LSER304
NSER304
OSER304

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:23186163
ChainResidueDetails
KSER320
LSER320
NSER320
OSER320

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754
ChainResidueDetails
KTHR323
LTHR323
NTHR323
OTHR323

site_idSWS_FT_FI14
Number of Residues8
DetailsMOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
KSER327
KSER328
LSER327
LSER328
NSER327
NSER328
OSER327
OSER328

site_idSWS_FT_FI15
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:16478998
ChainResidueDetails
KLYS210
LLYS210
NLYS210
OLYS210

site_idSWS_FT_FI16
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26774286
ChainResidueDetails
KLYS296
LLYS296
NLYS296
OLYS296

222415

PDB entries from 2024-07-10

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