7Z6O
X-Ray studies of Ku70/80 reveal the binding site for IP6
Summary for 7Z6O
Entry DOI | 10.2210/pdb7z6o/pdb |
Descriptor | X-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 5, DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), ... (5 entities in total) |
Functional Keywords | dna repair; double-strand break; nhej, dna binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 170249.39 |
Authors | Varela, P.F.,Charbonnier, J.B. (deposition date: 2022-03-14, release date: 2023-08-30, Last modification date: 2023-12-06) |
Primary citation | Kefala Stavridi, A.,Gontier, A.,Morin, V.,Frit, P.,Ropars, V.,Barboule, N.,Racca, C.,Jonchhe, S.,Morten, M.J.,Andreani, J.,Rak, A.,Legrand, P.,Bourand-Plantefol, A.,Hardwick, S.W.,Chirgadze, D.Y.,Davey, P.,De Oliveira, T.M.,Rothenberg, E.,Britton, S.,Calsou, P.,Blundell, T.L.,Varela, P.F.,Chaplin, A.K.,Charbonnier, J.B. Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51:11732-11747, 2023 Cited by PubMed: 37870477DOI: 10.1093/nar/gkad863 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
Download full validation report