7ZT6

Cryo-EM structure of Ku 70/80 bound to inositol hexakisphosphate

Summary for 7ZT6

• Entry DOI: 10.2210/pdb7zt6/pdb
• EMDB information: 14955
• Descriptor: X-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 5, INOSITOL HEXAKISPHOSPHATE (3 entities in total)
• Functional Keywords: dna repair, nhej, ku 70/80, dna-pk, cancer, double-strand break, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 157362.81

Authors

Kefala Stavridi, A.,Chaplin, A.K.,Blundell, T.L. (deposition date: 2022-05-09, release date: 2023-05-17, Last modification date: 2023-12-06)

• Primary citation: Kefala Stavridi, A.,Gontier, A.,Morin, V.,Frit, P.,Ropars, V.,Barboule, N.,Racca, C.,Jonchhe, S.,Morten, M.J.,Andreani, J.,Rak, A.,Legrand, P.,Bourand-Plantefol, A.,Hardwick, S.W.,Chirgadze, D.Y.,Davey, P.,De Oliveira, T.M.,Rothenberg, E.,Britton, S.,Calsou, P.,Blundell, T.L.,Varela, P.F.,Chaplin, A.K.,Charbonnier, J.B.; Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.; Nucleic Acids Res., 51:11732-11747, 2023; PubMed: 37870477; DOI: 10.1093/nar/gkad863

Experimental method

ELECTRON MICROSCOPY (3.5 Å)