8BHY

DNA-PK Ku80 mediated dimer bound to PAXX and XLF

Summary for 8BHY

• Entry DOI: 10.2210/pdb8bhy/pdb
• EMDB information: 16074
• Descriptor: DNA-dependent protein kinase catalytic subunit, DNA (5'-D(P*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*G)-3'), Non-homologous end-joining factor 1, ... (11 entities in total)
• Functional Keywords: dna-pk, dna-pkcs, ku70, ku80, paxx, nhej, dna binding protein, xlf
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 20
• Total formula weight: 1747962.06

Authors

Hardwick, S.W.,Chaplin, A.K. (deposition date: 2022-11-01, release date: 2023-06-07, Last modification date: 2023-06-14)

• Primary citation: Seif-El-Dahan, M.,Kefala-Stavridi, A.,Frit, P.,Hardwick, S.W.,Chirgadze, D.Y.,Maia De Oliviera, T.,Britton, S.,Barboule, N.,Bossaert, M.,Pandurangan, A.P.,Meek, K.,Blundell, T.L.,Ropars, V.,Calsou, P.,Charbonnier, J.B.,Chaplin, A.K.; PAXX binding to the NHEJ machinery explains functional redundancy with XLF.; Sci Adv, 9:eadg2834-eadg2834, 2023; PubMed: 37256950; DOI: 10.1126/sciadv.adg2834

Experimental method

ELECTRON MICROSCOPY (5.33 Å)