5M05

Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP form

Summary for 5M05

• Entry DOI: 10.2210/pdb5m05/pdb
• Descriptor: Myosin-11, 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: myosin inhibitor, motor protein
• Biological source: Gallus gallus (Chicken)
• Cellular location: Cytoplasm, myofibril: P10587
• Total number of polymer chains: 1
• Total formula weight: 92398.97

Authors

Sirigu, S.,Hartman, J.,Houdusse, A. (deposition date: 2016-10-03, release date: 2016-11-16, Last modification date: 2024-01-17)

• Primary citation: Sirigu, S.,Hartman, J.J.,Planelles-Herrero, V.J.,Ropars, V.,Clancy, S.,Wang, X.,Chuang, G.,Qian, X.,Lu, P.P.,Barrett, E.,Rudolph, K.,Royer, C.,Morgan, B.P.,Stura, E.A.,Malik, F.I.,Houdusse, A.M.; Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.; Proc. Natl. Acad. Sci. U.S.A., 113:E7448-E7455, 2016; PubMed: 27815532; DOI: 10.1073/pnas.1609342113

Experimental method

X-RAY DIFFRACTION (2.675 Å)