5T45
Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP.BeFx form
Summary for 5T45
Entry DOI | 10.2210/pdb5t45/pdb |
Descriptor | Myosin-11, 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, MAGNESIUM ION, ... (8 entities in total) |
Functional Keywords | myosin inhibitor, motor protein |
Biological source | Gallus gallus (Chicken) |
Total number of polymer chains | 1 |
Total formula weight | 93033.57 |
Authors | Sirigu, S.,Planelles-Herrero, V.J.,Hartman, J.,Houdusse, A. (deposition date: 2016-08-29, release date: 2016-11-16, Last modification date: 2024-01-17) |
Primary citation | Sirigu, S.,Hartman, J.J.,Planelles-Herrero, V.J.,Ropars, V.,Clancy, S.,Wang, X.,Chuang, G.,Qian, X.,Lu, P.P.,Barrett, E.,Rudolph, K.,Royer, C.,Morgan, B.P.,Stura, E.A.,Malik, F.I.,Houdusse, A.M. Highly selective inhibition of myosin motors provides the basis of potential therapeutic application. Proc. Natl. Acad. Sci. U.S.A., 113:E7448-E7455, 2016 Cited by PubMed: 27815532DOI: 10.1073/pnas.1609342113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report