7ZYG

CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF

Summary for 7ZYG

Entry DOI	10.2210/pdb7zyg/pdb
EMDB information	15022
Descriptor	X-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 5, Protein PAXX, ... (7 entities in total)
Functional Keywords	nhej, ku70, ku80, dna damage, dna binding protein, xlf
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	217065.19
Authors	Hardwick, S.W.,Kefala-Stavridi, A.,Chirgadze, D.Y.,Blundell, T.L.,Chaplin, A.K. (deposition date: 2022-05-24, release date: 2023-06-07, Last modification date: 2023-06-14)
Primary citation	Seif-El-Dahan, M.,Kefala-Stavridi, A.,Frit, P.,Hardwick, S.W.,Chirgadze, D.Y.,Maia De Oliviera, T.,Britton, S.,Barboule, N.,Bossaert, M.,Pandurangan, A.P.,Meek, K.,Blundell, T.L.,Ropars, V.,Calsou, P.,Charbonnier, J.B.,Chaplin, A.K. PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9:eadg2834-eadg2834, 2023 Cited by PubMed: 37256950 DOI: 10.1126/sciadv.adg2834 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.68 Å)

Structure validation