7ZYG
CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | X-ray repair cross-complementing protein 6 | polymer | 609 | 69945.0 | 1 | UniProt (P12956) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF02037) In PDB | Homo sapiens (human) | 5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTCBF,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Ku70,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 6 |
| 2 | B | X-ray repair cross-complementing protein 5 | polymer | 732 | 82812.4 | 1 | UniProt (P13010) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF08785) In PDB | Homo sapiens (human) | 86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTCBF,DNA repair protein XRCC5,Ku80,Ku86,Lupus Ku autoantigen protein p86,Nuclear factor IV,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) |
| 3 | C | Protein PAXX | polymer | 204 | 21663.5 | 1 | UniProt (Q9BUH6) Pfam (PF15384) In PDB | Homo sapiens (human) | Paralog of XRCC4 and XLF,XRCC4-like small protein |
| 4 | F | Non-homologous end-joining factor 1 | polymer | 299 | 33372.2 | 1 | UniProt (Q9H9Q4) Pfam (PF09302) Pfam (PF21928) In PDB | Homo sapiens (human) | Protein cernunnos,XRCC4-like factor |
| 5 | D | DNA | polymer | 15 | 4503.9 | 1 | Homo sapiens | ||
| 6 | E | DNA | polymer | 15 | 4673.1 | 1 | Homo sapiens | ||
| 7 | B | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 216970.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 95.0 | |
| All* | Total formula weight | 217065.2 |
