5WZM
| Crystal structure of human secreted phospholipase A2 group IIE | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Hou, S, Xu, J, Xu, T, Liu, J. | 登録日 | 2017-01-18 | 公開日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE Sci Rep, 7, 2017
|
|
5WZV
| Crystal structure of human secreted phospholipase A2 group IIE with Me-indoxam | 分子名称: | 2-[2-methyl-3-oxamoyl-1-[(2-phenylphenyl)methyl]indol-4-yl]oxyethanoic acid, CALCIUM ION, CHLORIDE ION, ... | 著者 | Hou, S, Xu, J, Xu, T, Liu, J. | 登録日 | 2017-01-18 | 公開日 | 2018-01-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE Sci Rep, 7, 2017
|
|
8XLO
| |
8XLQ
| |
8IFO
| Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter | 分子名称: | DNA (5'-D(*GP*AP*GP*GP*AP*CP*AP*AP*AP*GP*GP*TP*GP*AP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*TP*CP*AP*CP*CP*TP*TP*TP*GP*TP*CP*CP*TP*C)-3'), Estrogen-related receptor gamma, ... | 著者 | Xu, T, Zhen, X, Liu, J. | 登録日 | 2023-02-19 | 公開日 | 2023-03-29 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | ERR gamma-DBD undergoes dimerization and conformational rearrangement upon binding to the downstream site of the DR1 element. Biochem.Biophys.Res.Commun., 656, 2023
|
|
6L6L
| Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements | 分子名称: | DNA (5'-D(*AP*AP*AP*GP*GP*TP*CP*AP*AP*AP*CP*TP*GP*TP*GP*AP*CP*CP*TP*AP*T)-3'), DNA (5'-D(P*TP*AP*TP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*TP*TP*GP*AP*CP*CP*TP*T)-3'), Nuclear receptor related 1, ... | 著者 | Jiang, L, Chen, Y. | 登録日 | 2019-10-29 | 公開日 | 2019-11-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.781 Å) | 主引用文献 | Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements. J.Biol.Chem., 294, 2019
|
|
6L6Q
| |
6LBM
| |
6LBI
| |
6LHD
| Crystal structure of p53/BCL-xL fusion complex | 分子名称: | ZINC ION, fusion protein of Bcl-2-like protein 1 and Isoform 6 of Cellular tumor antigen p53 | 著者 | Wei, H, Chen, Y. | 登録日 | 2019-12-07 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.499 Å) | 主引用文献 | Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis. Nat Commun, 12, 2021
|
|
6L8L
| C-Src in complex with ibrutinib | 分子名称: | 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, Proto-oncogene tyrosine-protein kinase Src | 著者 | Guo, M, Dai, S, Chen, L, Chen, Y. | 登録日 | 2019-11-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.888 Å) | 主引用文献 | Characterization of ibrutinib as a non-covalent inhibitor of SRC-family kinases. Bioorg.Med.Chem.Lett., 34, 2020
|
|
6LC1
| |
7V29
| Crystal structure of FGFR4 with a dual-warhead covalent inhhibitor | 分子名称: | Fibroblast growth factor receptor 4, N-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4H-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide, SULFATE ION | 著者 | Chen, X.J, Jiang, L.Y, Dai, S.Y, Qu, L.Z, Chen, Y.H. | 登録日 | 2021-08-07 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.983 Å) | 主引用文献 | Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun Chem, 5, 2022
|
|
5JZV
| The structure of D77G hCINAP-ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Adenylate kinase isoenzyme 6 | 著者 | Liu, Y, Yang, Z, Yang, Y, Cai, X, Zheng, X. | 登録日 | 2016-05-17 | 公開日 | 2016-08-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth. Nat Commun, 7, 2016
|
|
6AKP
| Crystal Structural of FOXC2 DNA binding domain bound to PC promoter | 分子名称: | DNA (5'-D(AP*CP*AP*CP*AP*AP*AP*TP*AP*TP*TP*TP*GP*TP*GP*T)-3'), Forkhead box protein C2, MAGNESIUM ION | 著者 | Chen, X, Wei, H, Li, J, Liang, X, Dai, S, Jiang, L, Guo, M, Chen, Y. | 登録日 | 2018-09-03 | 公開日 | 2019-02-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.323 Å) | 主引用文献 | Structural basis for DNA recognition by FOXC2. Nucleic Acids Res., 47, 2019
|
|
6AKO
| Crystal Structure of FOXC2 DBD Bound to DBE2 DNA | 分子名称: | DNA (5'-D(CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Forkhead box protein C2, ... | 著者 | Chen, X, Wei, H, Li, J, Liang, X, Dai, S, Jiang, L, Guo, M, Chen, Y. | 登録日 | 2018-09-03 | 公開日 | 2019-02-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.396 Å) | 主引用文献 | Structural basis for DNA recognition by FOXC2. Nucleic Acids Res., 47, 2019
|
|
5JKG
| |
5XFF
| |
5Y5E
| Crystal structure of phospholipase A2 with inhibitor | 分子名称: | 2-[2-methyl-3-oxamoyl-1-[[2-(trifluoromethyl)phenyl]methyl]indol-4-yl]oxyethanoic acid, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | 著者 | Hou, S, Xu, J, Xu, T, Liu, J. | 登録日 | 2017-08-08 | 公開日 | 2018-06-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2group IIE Sci Rep, 7, 2017
|
|
5ZTY
| Crystal structure of human G protein coupled receptor | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Li, X.T, Hua, T, Wu, L.J, Liu, Z.J. | 登録日 | 2018-05-05 | 公開日 | 2019-01-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of the Human Cannabinoid Receptor CB2 Cell, 176, 2019
|
|
5WZT
| Crystal structure of human secreted phospholipase A2 group IIE with Compound 14 | 分子名称: | 2-[1-[(3-bromophenyl)methyl]-2-methyl-3-oxamoyl-indol-4-yl]oxyethanoic acid, CALCIUM ION, DIMETHYL SULFOXIDE, ... | 著者 | Hou, S, Xu, J, Xu, T, Liu, J. | 登録日 | 2017-01-18 | 公開日 | 2018-01-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE Sci Rep, 7, 2017
|
|
5WZO
| Crystal structure of human secreted phospholipase A2 group IIE, crystallized with calcium | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Hou, S, Xu, J, Xu, T, Liu, J. | 登録日 | 2017-01-18 | 公開日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE Sci Rep, 7, 2017
|
|
5WZU
| Crystal structure of human secreted phospholipase A2 group IIE with Compound 24 | 分子名称: | 2-[2-methyl-3-oxamoyl-1-[[2-(trifluoromethyl)phenyl]methyl]indol-4-yl]oxyethanoic acid, CALCIUM ION, CHLORIDE ION, ... | 著者 | Hou, S, Xu, J, Xu, T, Liu, J. | 登録日 | 2017-01-18 | 公開日 | 2018-01-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE Sci Rep, 7, 2017
|
|
5WZW
| Crystal structure of human secreted phospholipase A2 group IIE with LY311727 | 分子名称: | (3-{[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethyl-1H-indol-5-yl]oxy}propyl)phosphonic acid, CALCIUM ION, CHLORIDE ION, ... | 著者 | Hou, S, Xu, J, Xu, T, Liu, J. | 登録日 | 2017-01-18 | 公開日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE Sci Rep, 7, 2017
|
|
8GVJ
| Crystal structure of cMET kinase domain bound by D6808 | 分子名称: | (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor | 著者 | Chen, Y.H, Qu, L.Z. | 登録日 | 2022-09-15 | 公開日 | 2022-11-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65, 2022
|
|