5WZU

Crystal structure of human secreted phospholipase A2 group IIE with Compound 24

Summary for 5WZU

• Entry DOI: 10.2210/pdb5wzu/pdb
• Related: 5WZM 5WZO 5WZS 5WZT 5WZV 5WZW
• Descriptor: Group IIE secretory phospholipase A2, CALCIUM ION, 2-[2-methyl-3-oxamoyl-1-[[2-(trifluoromethyl)phenyl]methyl]indol-4-yl]oxyethanoic acid, ... (7 entities in total)
• Functional Keywords: phospholipase a2, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: Q9NZK7
• Total number of polymer chains: 1
• Total formula weight: 14701.71

Authors

Hou, S.,Xu, J.,Xu, T.,Liu, J. (deposition date: 2017-01-18, release date: 2018-01-24, Last modification date: 2023-11-22)

• Primary citation: Hou, S.,Xu, T.,Xu, J.,Qu, L.,Xu, Y.,Chen, L.,Liu, J.; Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE; Sci Rep, 7:10815-10815, 2017; PubMed: 28883454; DOI: 10.1038/s41598-017-11219-8

Experimental method

X-RAY DIFFRACTION (2.2 Å)