5JKG

The crystal structure of FGFR4 kinase domain in complex with LY2874455

Summary for 5JKG

• Entry DOI: 10.2210/pdb5jkg/pdb
• Descriptor: Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol (3 entities in total)
• Functional Keywords: kinase, small-molecule inhibitor, atp binding pocket, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Cytoplasm : P22455
• Total number of polymer chains: 1
• Total formula weight: 35135.39

Authors

Wu, D.,Chen, L.,Chen, Y. (deposition date: 2016-04-26, release date: 2016-10-05, Last modification date: 2024-03-20)

• Primary citation: Wu, D.,Guo, M.,Philips, M.A.,Qu, L.,Jiang, L.,Li, J.,Chen, X.,Chen, Z.,Chen, L.,Chen, Y.; Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455; Plos One, 11:e0162491-e0162491, 2016; PubMed: 27618313; DOI: 10.1371/journal.pone.0162491

Experimental method

X-RAY DIFFRACTION (2.352 Å)