5JKG
The crystal structure of FGFR4 kinase domain in complex with LY2874455
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 4 | polymer | 311 | 34691.1 | 1 | UniProt (P22455) Pfam (PF07714) | Homo sapiens (Human) | FGFR-4 |
| 2 | B (A) | 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol | non-polymer | 444.3 | 1 | Chemie (6LF) | |||
| 3 | C (A) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A: 445 - 753 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Gly 443 | - | expression tag |
| Pro 444 | - | expression tag |
| Ala 477 | Cys 477 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34691.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 444.3 | |
| All* | Total formula weight | 35135.4 |
