7WCL

Crystal structure of FGFR1 kinase domain with Pemigatinib

Summary for 7WCL

Entry DOI	10.2210/pdb7wcl/pdb
Descriptor	Fibroblast growth factor receptor 1, 11-[2,6-bis(fluoranyl)-3,5-dimethoxy-phenyl]-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),3,7-tetraen-12-one, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase, inhibitor, complex, structural protein, transferase-transferase inhibitor complex, tra, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	72080.42
Authors	Chen, X.J.,Lin, Q.M.,Jiang, L.Y.,Qu, L.Z.,Chen, Y.H. (deposition date: 2021-12-20, release date: 2022-09-14, Last modification date: 2023-11-29)
Primary citation	Lin, Q.,Chen, X.,Qu, L.,Guo, M.,Wei, H.,Dai, S.,Jiang, L.,Chen, Y. Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants. Commun Chem, 5:100-100, 2022 Cited by PubMed: 36698015 DOI: 10.1038/s42004-022-00718-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.495 Å)

Structure validation