4RWN
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![BU of 4rwn by Molmil](/molmil-images/mine/4rwn) | Crystal structure of the pre-reactive state of porcine OAS1 | 分子名称: | 2'-5'-oligoadenylate synthase 1, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, ... | 著者 | Lohoefener, J, Steinke, N, Kay-Fedorov, P, Baruch, P, Nikulin, A, Tishchenko, S, Manstein, D.J, Fedorov, R. | 登録日 | 2014-12-05 | 公開日 | 2015-05-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. Structure, 23, 2015
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4RWQ
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![BU of 4rwq by Molmil](/molmil-images/mine/4rwq) | Crystal structure of the apo-state of porcine OAS1 | 分子名称: | 2'-5'-oligoadenylate synthase 1 | 著者 | Lohoefener, J, Steinke, N, Kay-Fedorov, P, Baruch, P, Nikulin, A, Tishchenko, S, Manstein, D.J, Fedorov, R. | 登録日 | 2014-12-05 | 公開日 | 2015-05-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. Structure, 23, 2015
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4RWO
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![BU of 4rwo by Molmil](/molmil-images/mine/4rwo) | Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the AMP donor position | 分子名称: | 2'-5'-oligoadenylate synthase 1, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, ... | 著者 | Lohoefener, J, Steinke, N, Kay-Fedorov, P, Baruch, P, Nikulin, A, Tishchenko, S, Manstein, D.J, Fedorov, R. | 登録日 | 2014-12-05 | 公開日 | 2015-05-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. Structure, 23, 2015
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5NZJ
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![BU of 5nzj by Molmil](/molmil-images/mine/5nzj) | Crystal structure of UDP-glucose pyrophosphorylase G45Y mutant from Leishmania major in complex with UDP-glucose | 分子名称: | 1,2-ETHANEDIOL, SULFATE ION, UDP-glucose pyrophosphorylase, ... | 著者 | Cramer, J.T, Fuehring, J.I, Baruch, P, Bruetting, C, Hesse, R, Knoelker, H.-J, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2017-05-14 | 公開日 | 2018-04-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies Acs Catalysis, 8, 2018
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5NZH
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![BU of 5nzh by Molmil](/molmil-images/mine/5nzh) | Crystal structure of UDP-glucose pyrophosphorylase V402W mutant from Leishmania major | 分子名称: | UDP-glucose pyrophosphorylase | 著者 | Cramer, J.T, Fuehring, J.I, Baruch, P, Bruetting, C, Hesse, R, Knoelker, H.-J, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2017-05-14 | 公開日 | 2018-04-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies Acs Catalysis, 8, 2018
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5NZK
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![BU of 5nzk by Molmil](/molmil-images/mine/5nzk) | Crystal structure of UDP-glucose pyrophosphorylase from Leishmania major in complex with phenylalanine | 分子名称: | PHENYLALANINE, SULFATE ION, UDP-glucose pyrophosphorylase | 著者 | Cramer, J.T, Fuehring, J.I, Baruch, P, Bruetting, C, Hesse, R, Knoelker, H.-J, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2017-05-14 | 公開日 | 2018-04-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies Acs Catalysis, 8, 2018
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6YUV
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![BU of 6yuv by Molmil](/molmil-images/mine/6yuv) | Capsule O-acetyltransferase of Neisseria meningitidis serogroup A | 分子名称: | CHLORIDE ION, SacC, TRIETHYLENE GLYCOL | 著者 | Cramer, J.T, Fiebig, T, Fedorov, R, Muehlenhoff, M. | 登録日 | 2020-04-27 | 公開日 | 2020-08-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A. Nat Commun, 11, 2020
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6YUQ
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![BU of 6yuq by Molmil](/molmil-images/mine/6yuq) | Capsule O-acetyltransferase of Neisseria meningitidis serogroup A in complex with polysaccharide | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-mannopyranose, 2-acetamido-2-deoxy-alpha-D-mannopyranose, ... | 著者 | Cramer, J.T, Fiebig, T, Fedorov, R, Muehlenhoff, M. | 登録日 | 2020-04-27 | 公開日 | 2020-08-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A. Nat Commun, 11, 2020
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6YUO
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![BU of 6yuo by Molmil](/molmil-images/mine/6yuo) | Capsule O-acetyltransferase of Neisseria meningitidis serogroup A in complex with caged Gadolinium | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Cramer, J.T, Fiebig, T, Fedorov, R, Muehlenhoff, M. | 登録日 | 2020-04-27 | 公開日 | 2020-08-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A. Nat Commun, 11, 2020
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6YUS
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![BU of 6yus by Molmil](/molmil-images/mine/6yus) | Capsule O-acetyltransferase of Neisseria meningitidis serogroup A H228A mutant in complex with CoA | 分子名称: | 1,2-ETHANEDIOL, COENZYME A, DI(HYDROXYETHYL)ETHER, ... | 著者 | Cramer, J.T, Fiebig, T, Fedorov, R, Muehlenhoff, M. | 登録日 | 2020-04-27 | 公開日 | 2020-08-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A. Nat Commun, 11, 2020
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5MEX
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![BU of 5mex by Molmil](/molmil-images/mine/5mex) | Sulphotransferase-18 from Arabidopsis thaliana in complex with 3'-phosphoadenosine 5'-phosphate (PAP)and sinigrin | 分子名称: | 1,2-ETHANEDIOL, 1,3-BUTANEDIOL, 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Hirschmann, F, Krause, F, Baruch, P, Chizhov, I, Mueller, J.W, Manstein, D.J, Papenbrock, J, Fedorov, R. | 登録日 | 2016-11-16 | 公開日 | 2017-07-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism. Sci Rep, 7, 2017
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5MEK
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![BU of 5mek by Molmil](/molmil-images/mine/5mek) | Sulphotransferase-18 from Arabidopsis thaliana in complex with 3'-phosphoadenosine 5'-phosphate (PAP) | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-3'-5'-DIPHOSPHATE, Cytosolic sulfotransferase 18, ... | 著者 | Hirschmann, F, Krause, F, Baruch, P, Chizhov, I, Mueller, J.W, Manstein, D.J, Papenbrock, J, Fedorov, R. | 登録日 | 2016-11-15 | 公開日 | 2017-07-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism. Sci Rep, 7, 2017
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2XEL
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![BU of 2xel by Molmil](/molmil-images/mine/2xel) | Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity | 分子名称: | 2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ... | 著者 | Chinthalapudi, K, Taft, M.H, Martin, R, Hartmann, F.K, Heissler, S.M, Tsiavaliaris, G, Gutzeit, H.O, Knoelker, H.J, Coluccio, L.M, Fedorov, R, Manstein, D.J. | 登録日 | 2010-05-16 | 公開日 | 2011-06-15 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity. J.Biol.Chem., 286, 2011
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4R7P
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![BU of 4r7p by Molmil](/molmil-images/mine/4r7p) | Human UDP-glucose pyrophosphorylase isoform 1 in complex with UDP-glucose | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ... | 著者 | Fuehring, J, Cramer, J.T, Schneider, J, Baruch, P, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2014-08-28 | 公開日 | 2015-04-22 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism. Sci Rep, 5
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4M28
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![BU of 4m28 by Molmil](/molmil-images/mine/4m28) | UDP-Glucose Pyrophosphorylase from Leishmania major in complex with UTP analog dUpCpp | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridine, UDP-glucose pyrophosphorylase | 著者 | Fuehring, J.I, Routier, F.H, Lamerz, A.-C, Baruch, P, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2013-08-05 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Catalytic mechanism and allosteric regulation of UDP-glucose pyrophosphorylase from Leishmania major ACS CATALYSIS, 3, 2013
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4M2A
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![BU of 4m2a by Molmil](/molmil-images/mine/4m2a) | Crystal structure of the udp-glucose pyrophosphorylase from Leishmania major in the post-reactive state | 分子名称: | MAGNESIUM ION, SULFATE ION, UDP-glucose pyrophosphorylase, ... | 著者 | Fuehring, J, Routier, F.H, Lamerz, A.-C, Baruch, P, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2013-08-05 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Catalytic Mechanism and Allosteric Regulation of Udp-Glucose Pyrophosphorylase from Leishmania Major ACS CATALYSIS, 3, 2013
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4M2B
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![BU of 4m2b by Molmil](/molmil-images/mine/4m2b) | Crystal structure of L281D mutant of udp-glucose pyrophosphorylase from leishmania major in complex with udp-glc | 分子名称: | UDP-glucose pyrophosphorylase, URIDINE-5'-DIPHOSPHATE-GLUCOSE | 著者 | Fuehring, J, Routier, F.H, Lamerz, A.-C, Baruch, P, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2013-08-05 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Catalytic Mechanism and Allosteric Regulation of Udp-Glucose Pyrophosphorylase from Leishmania Major ACS Catalysis, 36329, 2013
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4J18
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![BU of 4j18 by Molmil](/molmil-images/mine/4j18) | Crystal structure of H191L mutant of UDP-glucose pyrophosphorylase from Leishmania major | 分子名称: | UDP-glucose pyrophosphorylase | 著者 | Fuehring, J.I, Routier, F.H, Lamerz, A.-C, Baruch, P, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2013-02-01 | 公開日 | 2014-01-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Catalytic Mechanism and Allosteric Regulation of UDP-Glucose Pyrophosphorylase from Leishmania major ACS CATALYSIS, 3, 2013
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2Y9E
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![BU of 2y9e by Molmil](/molmil-images/mine/2y9e) | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | 分子名称: | MYOSIN-2 | 著者 | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | 登録日 | 2011-02-14 | 公開日 | 2011-07-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.397 Å) | 主引用文献 | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V. J.Biol.Chem., 286, 2011
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1CJS
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![BU of 1cjs by Molmil](/molmil-images/mine/1cjs) | CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN L1 FROM METHANOCOCCUS JANNASCHII | 分子名称: | 50S RIBOSOMAL PROTEIN L1P | 著者 | Nevskaya, N, Tishchenko, S, Fedorov, R, Al-Karadaghi, S, Liljas, A, Kraft, A, Piendl, W, Garber, M, Nikonov, S. | 登録日 | 1999-04-19 | 公開日 | 2000-05-31 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Archaeal ribosomal protein L1: the structure provides new insights into RNA binding of the L1 protein family. Structure Fold.Des., 8, 2000
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2Y0R
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![BU of 2y0r by Molmil](/molmil-images/mine/2y0r) | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | 分子名称: | MYOSIN-2 HEAVY CHAIN | 著者 | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | 登録日 | 2010-12-07 | 公開日 | 2011-07-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V. J.Biol.Chem., 286, 2011
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1ZVI
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![BU of 1zvi by Molmil](/molmil-images/mine/1zvi) | Rat Neuronal Nitric Oxide Synthase Oxygenase Domain | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric-oxide synthase, brain, ... | 著者 | Matter, H, Kumar, H.S, Fedorov, R, Frey, A, Kotsonis, P, Hartmann, E, Frohlich, L.G, Reif, A, Pfleiderer, W, Scheurer, P, Ghosh, D.K, Schlichting, I, Schmidt, H.H. | 登録日 | 2005-06-02 | 公開日 | 2005-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Analysis of Isoform-Specific Inhibitors Targeting the Tetrahydrobiopterin Binding Site of Human Nitric Oxide Synthases. J.Med.Chem., 48, 2005
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1ZVL
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![BU of 1zvl by Molmil](/molmil-images/mine/1zvl) | Rat Neuronal Nitric Oxide Synthase Oxygenase Domain complexed with natural substrate L-Arg. | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, Nitric-oxide synthase, ... | 著者 | Matter, H, Kumar, H.S, Fedorov, R, Frey, A, Kotsonis, P, Hartmann, E, Frohlich, L.G, Reif, A, Pfleiderer, W, Scheurer, P, Ghosh, D.K, Schlichting, I, Schmidt, H.H. | 登録日 | 2005-06-02 | 公開日 | 2005-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Analysis of Isoform-Specific Inhibitors Targeting the Tetrahydrobiopterin Binding Site of Human Nitric Oxide Synthases. J.Med.Chem., 48, 2005
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5NZI
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![BU of 5nzi by Molmil](/molmil-images/mine/5nzi) | Crystal structure of UDP-glucose pyrophosphorylase S374F mutant from Leishmania major in complex with UDP-glucose | 分子名称: | 1,2-ETHANEDIOL, UDP-glucose pyrophosphorylase, URIDINE-5'-DIPHOSPHATE-GLUCOSE | 著者 | Cramer, J.T, Fuehring, J.I, Baruch, P, Bruetting, C, Hesse, R, Knoelker, H.-J, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2017-05-14 | 公開日 | 2018-04-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies Acs Catalysis, 8, 2018
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5NZG
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![BU of 5nzg by Molmil](/molmil-images/mine/5nzg) | Crystal structure of UDP-glucose pyrophosphorylase S374W mutant from Leishmania major in complex with UDP-glucose | 分子名称: | 1,2-ETHANEDIOL, UDP-glucose pyrophosphorylase, URIDINE-5'-DIPHOSPHATE-GLUCOSE | 著者 | Cramer, J.T, Fuehring, J.I, Baruch, P, Bruetting, C, Hesse, R, Knoelker, H.-J, Gerardy-Schahn, R, Fedorov, R. | 登録日 | 2017-05-14 | 公開日 | 2018-04-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies Acs Catalysis, 8, 2018
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