5NZG

Crystal structure of UDP-glucose pyrophosphorylase S374W mutant from Leishmania major in complex with UDP-glucose

Summary for 5NZG

Entry DOI	10.2210/pdb5nzg/pdb
Related	2OEF 2OEG 4J18 4M28 4M2A 4M2B
Descriptor	UDP-glucose pyrophosphorylase, URIDINE-5'-DIPHOSPHATE-GLUCOSE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	ntp-transferase, pathogen, allostery, catalysis, transferase
Biological source	Leishmania major
Total number of polymer chains	1
Total formula weight	57527.09
Authors	Cramer, J.T.,Fuehring, J.I.,Baruch, P.,Bruetting, C.,Hesse, R.,Knoelker, H.-J.,Gerardy-Schahn, R.,Fedorov, R. (deposition date: 2017-05-14, release date: 2018-04-18, Last modification date: 2024-01-17)
Primary citation	Cramer, J.T.,Fuehring, J.I.,Baruch, P.,Bruetting, C.,Knoelker, H.-J.,Gerardy-Schahn, R.,Fedorov, R. Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies Acs Catalysis, 8:-, 2018 Cited by DOI: 10.1021/acscatal.7b03714 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation