5NZG

Crystal structure of UDP-glucose pyrophosphorylase S374W mutant from Leishmania major in complex with UDP-glucose

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	UDP-glucose pyrophosphorylase	polymer	505	56153.9	1	UniProt (Q4QDU3) Pfam (PF01704) In PDB	Leishmania major
2	A	URIDINE-5'-DIPHOSPHATE-GLUCOSE	non-polymer		566.3	1	Chemie (UPG)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	13	Chemie (EDO)
4		water	water		18.0	417	Chemie (HOH)

Sequence modifications

A: 1 - 494 (UniProt: Q4QDU3)

PDB	External Database	Details
Trp 374	Ser 374	engineered mutation
Met 495	-	expression tag
Arg 496	-	expression tag
Pro 497	-	expression tag
Leu 498	-	expression tag
Glu 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag
His 502	-	expression tag
His 503	-	expression tag
His 504	-	expression tag
His 505	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56153.9
Non-Polymers*	Number of molecules	14
	Total formula weight	1373.2
All*	Total formula weight	57527.1

*Water molecules are not included.