5NZG

Crystal structure of UDP-glucose pyrophosphorylase S374W mutant from Leishmania major in complex with UDP-glucose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0006011	biological_process	UDP-alpha-D-glucose metabolic process
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031981	cellular_component	nuclear lumen
A	0070569	molecular_function	uridylyltransferase activity
A	0097014	cellular_component	ciliary plasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	binding site for residue UPG A 601

Chain	Residue
A	LEU81
A	GLY220
A	ASP221
A	GLY256
A	GLY257
A	GLU284
A	PHE305
A	ASN306
A	ASN308
A	PHE376
A	LYS380
A	GLY83
A	HOH774
A	HOH791
A	HOH811
A	HOH829
A	HOH836
A	HOH847
A	HOH858
A	HOH867
A	HOH916
A	HOH933
A	GLY84
A	HOH991
A	MET130
A	GLN162
A	PRO188
A	GLY190
A	HIS191
A	ASN219

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 602

Chain	Residue
A	THR381
A	CYS382
A	ALA383
A	LEU416
A	SER418
A	HOH778

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 603

Chain	Residue
A	GLN74
A	GLN210
A	GLY211
A	TYR212
A	HOH711
A	HOH745

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 604

Chain	Residue
A	ASP93
A	SER138
A	SER141
A	PHE142

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO A 605

Chain	Residue
A	LEU198
A	TYR199
A	GLY202
A	LEU204
A	GLN205
A	GLN205
A	LEU318

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 606

Chain	Residue
A	THR65
A	GLN170
A	PRO347
A	LYS348

---

site_id	AC7
Number of Residues	9
Details	binding site for residue EDO A 607

Chain	Residue
A	GLY224
A	ARG373
A	TRP374
A	PHE376
A	ALA377
A	TYR393
A	LEU401
A	VAL402
A	LEU403

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 608

Chain	Residue
A	ALA34
A	GLN35
A	LEU330
A	VAL332
A	HOH937
A	HOH977
A	HOH1087

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO A 609

Chain	Residue
A	THR250
A	GLU251
A	SER252
A	HIS410
A	PRO411
A	VAL413
A	LYS442
A	HOH704

---

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO A 610

Chain	Residue
A	TRP374
A	ARG400

---

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO A 611

Chain	Residue
A	CYS28
A	THR31
A	VAL165
A	ASP193
A	THR196
A	HOH787
A	HOH808

---

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO A 612

Chain	Residue
A	SER75
A	ARG213
A	GLU236
A	HOH701
A	HOH761

---

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO A 613

Chain	Residue
A	LEU8
A	ARG30
A	HOH882

---

site_id	AD5
Number of Residues	2
Details	binding site for residue EDO A 614

Chain	Residue
A	HOH711
A	GLN210

---