4R7P

Human UDP-glucose pyrophosphorylase isoform 1 in complex with UDP-glucose

Summary for 4R7P

• Entry DOI: 10.2210/pdb4r7p/pdb
• Related: 3R2W 3R3I
• Descriptor: UTP--glucose-1-phosphate uridylyltransferase, URIDINE-5'-DIPHOSPHATE-GLUCOSE, SULFATE ION, ... (7 entities in total)
• Functional Keywords: rossmann-like alpha/beta/alpha sandwich fold, pyrophosphorylase, utp, glc-1-p, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q16851
• Total number of polymer chains: 4
• Total formula weight: 239454.47

Authors

Fuehring, J.,Cramer, J.T.,Schneider, J.,Baruch, P.,Gerardy-Schahn, R.,Fedorov, R. (deposition date: 2014-08-28, release date: 2015-04-22, Last modification date: 2024-02-28)

• Primary citation: Fuhring, J.I.,Cramer, J.T.,Schneider, J.,Baruch, P.,Gerardy-Schahn, R.,Fedorov, R.; A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism.; Sci Rep, 5:9618-9618, ; PubMed: 25860585; DOI: 10.1038/srep09618

Experimental method

X-RAY DIFFRACTION (3.35 Å)