Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4R7P

Human UDP-glucose pyrophosphorylase isoform 1 in complex with UDP-glucose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0005978	biological_process	glycogen biosynthetic process
A	0006011	biological_process	UDP-alpha-D-glucose metabolic process
A	0007420	biological_process	brain development
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
A	0070062	cellular_component	extracellular exosome
A	0070569	molecular_function	uridylyltransferase activity
B	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005977	biological_process	glycogen metabolic process
B	0005978	biological_process	glycogen biosynthetic process
B	0006011	biological_process	UDP-alpha-D-glucose metabolic process
B	0007420	biological_process	brain development
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
B	0070062	cellular_component	extracellular exosome
B	0070569	molecular_function	uridylyltransferase activity
C	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005977	biological_process	glycogen metabolic process
C	0005978	biological_process	glycogen biosynthetic process
C	0006011	biological_process	UDP-alpha-D-glucose metabolic process
C	0007420	biological_process	brain development
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
C	0070062	cellular_component	extracellular exosome
C	0070569	molecular_function	uridylyltransferase activity
D	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005977	biological_process	glycogen metabolic process
D	0005978	biological_process	glycogen biosynthetic process
D	0006011	biological_process	UDP-alpha-D-glucose metabolic process
D	0007420	biological_process	brain development
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
D	0070062	cellular_component	extracellular exosome
D	0070569	molecular_function	uridylyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UPG A 601

Chain	Residue
A	LEU113
A	ASN328
A	ASN330
A	ASN114
A	GLY115
A	GLY116
A	GLN190
A	HIS223
A	ASN251
A	ASP253
A	LYS291

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	GLU27
D	ASN179
D	HIS180

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 603

Chain	Residue
A	HIS482

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 604

Chain	Residue
A	HIS148

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 605

Chain	Residue
A	HIS180

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 606

Chain	Residue
A	TRP75
A	HIS314

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 607

Chain	Residue
A	GLU245
A	MET268

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 608

Chain	Residue
A	LYS438
A	ASP441

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 609

Chain	Residue
A	GLY433
A	SER434
A	SER461

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 610

Chain	Residue
A	LYS319
A	LYS473
A	GLU495

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 611

Chain	Residue
A	ASN166
A	ASP170
A	HOH717

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 612

Chain	Residue
A	GLN87
A	HIS266

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 613

Chain	Residue
D	LYS77

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 614

Chain	Residue
A	GLU47
A	HOH730

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 615

Chain	Residue
A	CYS123
A	GLN440
A	HOH727

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 601

Chain	Residue
B	HIS148
B	THR152

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 602

Chain	Residue
B	GLU29
B	HIS63

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 603

Chain	Residue
B	LYS319
B	GLU454
B	LYS473
B	GLU495

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 604

Chain	Residue
B	CYS123
B	LYS124
B	GLN440

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 605

Chain	Residue
A	LYS274
A	ASN381
B	ASP99

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 606

Chain	Residue
B	ASP507
C	LYS497

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 607

Chain	Residue
B	ARG444
B	ARG445
B	THR465

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN B 608

Chain	Residue
B	ASP170

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 609

Chain	Residue
B	ASN179
B	HIS180

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 610

Chain	Residue
B	HIS457
B	HIS457

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 601

Chain	Residue
C	HIS148
C	THR152

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 602

Chain	Residue
B	GLU27
B	LEU28
C	HIS180

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 603

Chain	Residue
C	GLU447
C	ASP507

site_id	DC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACT C 604

Chain	Residue
C	HIS482

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 605

Chain	Residue
B	LYS431
C	HIS508

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 606

Chain	Residue
C	GLY222
C	HIS223

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 607

Chain	Residue
C	GLU147
C	CYS181

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 608

Chain	Residue
C	ASP441
C	HOH722

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN C 609

Chain	Residue
C	GLN87
C	HIS266

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 601

Chain	Residue
D	HIS148
D	THR152
D	HOH706

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 602

Chain	Residue
A	ASN502
D	ASP484
D	ASN502

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 603

Chain	Residue
D	LEU443
D	ARG444
D	PHE446

site_id	EC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT D 604

Chain	Residue
B	GLY483
D	HIS482

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT D 605

Chain	Residue
D	GLU454
D	GLU495

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 606

Chain	Residue
D	LYS438
D	ASP441
D	HOH730

site_id	EC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN D 607

Chain	Residue
D	HOH721

site_id	EC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 608

Chain	Residue
D	GLU147
D	CYS181

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	204
Details	Region: {"description":"Oligomerization"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Region: {"description":"Critical for end-to-end subunit interaction"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9M9P3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25860585","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R7P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)