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4RWO

Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the AMP donor position

Summary for 4RWO
Entry DOI10.2210/pdb4rwo/pdb
Related4RWN 4RWP 4RWQ
DescriptorRNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3'), RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3'), 2'-5'-oligoadenylate synthase 1, ... (6 entities in total)
Functional Keywordsinnate immunity, interferon-induced, transferase-rna complex, transferase/rna
Biological sourceSus scrofa (pigs,swine,wild boar)
More
Cellular locationCytoplasm : Q29599
Total number of polymer chains3
Total formula weight53963.44
Authors
Lohoefener, J.,Steinke, N.,Kay-Fedorov, P.,Baruch, P.,Nikulin, A.,Tishchenko, S.,Manstein, D.J.,Fedorov, R. (deposition date: 2014-12-05, release date: 2015-05-20, Last modification date: 2024-02-28)
Primary citationLohofener, J.,Steinke, N.,Kay-Fedorov, P.,Baruch, P.,Nikulin, A.,Tishchenko, S.,Manstein, D.J.,Fedorov, R.
The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
Structure, 23:851-862, 2015
Cited by
PubMed: 25892109
DOI: 10.1016/j.str.2015.03.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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