Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the AMP donor position

Summary for 4RWO

Related4RWN 4RWQ 4RWP
DescriptorRNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3'), RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3'), 2'-5'-oligoadenylate synthase 1, ... (6 entities in total)
Functional Keywordsinnate immunity, interferon-induced, transferase-rna complex, transferase/rna
Biological sourceSus scrofa (pigs,swine,wild boar)
Cellular locationCytoplasm  Q29599
Total number of polymer chains3
Total molecular weight53963.44
Primary citation
Lohofener, J.,Steinke, N.,Kay-Fedorov, P.,Baruch, P.,Nikulin, A.,Tishchenko, S.,Manstein, D.J.,Fedorov, R.
The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
Structure, 23:851-862, 2015
PubMed: 25892109 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2015.03.012
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.238401.0%4.2%0.85MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report